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Shean J. Aujla
Researcher at University of Pittsburgh
Publications - 17
Citations - 3478
Shean J. Aujla is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Asthma & Chemokine. The author has an hindex of 13, co-authored 15 publications receiving 3216 citations. Previous affiliations of Shean J. Aujla include Boston Children's Hospital.
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Journal ArticleDOI
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
Shean J. Aujla,Yvonne R. Chan,Mingquan Zheng,Mingjian Fei,David J. Askew,Derek Pociask,Todd A. Reinhart,Florencia McAllister,Jennifer Edeal,Kristi Gaus,Shahid Husain,James L. Kreindler,Patricia J. Dubin,Joseph M. Pilewski,Mike M. Myerburg,Carol A Mason,Yoichiro Iwakura,Jay K. Kolls +17 more
TL;DR: Although both cytokines regulated CXC chemokines and granulocyte colony–stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury, and data support the concept that the TH17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites.
Journal ArticleDOI
Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program.
Anne M. Fitzpatrick,W. Gerald Teague,Deborah A. Meyers,Stephen P. Peters,Xingnan Li,Huashi Li,Sally E. Wenzel,Shean J. Aujla,Mario Castro,Leonard B. Bacharier,Benjamin Gaston,Eugene R. Bleecker,Wendy C. Moore +12 more
TL;DR: How children with severe asthma are distributed across a cluster analysis and how well these clusters conform to current definitions of asthma severity are determined.
Journal ArticleDOI
Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F
Rolf E. Kuestner,David W. Taft,Aaron C. Haran,Cameron S. Brandt,Ty Brender,Karen Lum,Brandon Harder,Okada Shannon L,Craig D. Ostrander,James L. Kreindler,Shean J. Aujla,Brian Reardon,Margaret D. Moore,Pamela Shea,Randall W. Schreckhise,Thomas R. Bukowski,Scott R. Presnell,Patricia I. Guerra-Lewis,Julia Parrish-Novak,Jeff L. Ellsworth,Stephen R. Jaspers,Katherine E. Lewis,Mark W. Appleby,Jay K. Kolls,Mark W. Rixon,James W. West,Zeren Gao,Steven D. Levin +27 more
TL;DR: IL-17RC functions as a receptor for both IL- 17A and IL-17F and that a soluble version of this protein should be an effective antagonist of IL-16A andIL-16F mediated inflammatory diseases.
Journal ArticleDOI
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations
Loren C. Denlinger,Brenda R. Phillips,Sima K. Ramratnam,Kristie R. Ross,Nirav R. Bhakta,Juan Carlos Cardet,Mario Castro,Stephen P. Peters,Wanda Phipatanakul,Shean J. Aujla,Leonard B. Bacharier,Eugene R. Bleecker,Suzy A. A. Comhair,Andrea M. Coverstone,Mark D. DeBoer,Serpil C. Erzurum,Sean B. Fain,Merritt L. Fajt,Anne M. Fitzpatrick,Jonathan M. Gaffin,Benjamin Gaston,Annette T. Hastie,Gregory A. Hawkins,Fernando Holguin,Anne Marie Irani,Elliot Israel,Bruce D. Levy,Ngoc P. Ly,Deborah A. Meyers,Wendy C. Moore,Ross Myers,Maria Theresa D. Opina,Michael C. Peters,Mark L. Schiebler,Ronald L. Sorkness,W. Gerald Teague,Sally E. Wenzel,Prescott G. Woodruff,David T. Mauger,John V. Fahy,Nizar N. Jarjour +40 more
TL;DR: Blood eosinophils, body mass index, and bronchodilator responsiveness were positively associated with exacerbation frequency in the SARP‐3 multivariable model, and EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies.
Journal ArticleDOI
Th17 cells and mucosal host defense.
TL;DR: Compared to Th1 cells, IL-23 and IL-17 show limited roles in controlling host defense against primary infections with intracellular bacteria such as Mycobacterium tuberculosis suggesting a predominate role of the Th17 lineage in hostdefense against extracellular pathogens.