Showing papers by "Mingwei Chen published in 2023"
TL;DR: Wang et al. as mentioned in this paper proposed a novel block division convolutional network (BDCNN) with the implicit deep features augmentation to handle the small sample size problem in the micro-expression data.
Abstract: Despite the development of computer vision techniques, the micro-expression (ME) recognition task still remains a great challenge because MEs have very low intensity and short duration. However, the ME recognition is of great significance since it provides important clues for real affective states detection. This paper proposes a novel Block Division Convolutional Network (BDCNN) with the implicit deep features augmentation. In detail, BDCNN learns from four optical flow features computed by the onset and apex frames of each video. It innovatively divides each image into a set of small blocks in the deep learning model, then the convolution and pooling operations are performed on these small blocks in sequence. To handle the small sample size problem in the micro-expression data, this study uses the improved implicit semantic data augmentation algorithm in the deep features space. Experiments are conducted on three publicly available databases, viz, CASME II, SMIC, and SAMM. Experimental results show that our model outperforms the state-of-the-art methods by attaining the accuracy of 84.32% and F1-score of 82.13% on the 3-class datasets, and the accuracy of 81.82% and F1-score of 75.46% on the 5-class datasets, respectively. Our source code is publicly available for non-commercial or research use at https://github.com/MLDMXM2017/BDCNN.
6 citations
TL;DR: In this article , the effects of MPs from poly (butyleneadipate-co-terephthalate)-based biodegradable mulch and polyethylene mulch (PM) in Cd- or As-contaminated soil on soil properties and speciation of HMs were characterised using Fourier-transform infrared spectroscopy (FTIR).
5 citations
TL;DR: In this paper , a dealloying strategy was proposed to activate the porous spinel NiFe2O4 nanowires with up to four metal cation substitutions.
Abstract: Cost-effective electrochemical water splitting technology hinges on the development of efficient and durable catalysts for oxygen evolution reaction (OER). Spinel oxides (formula: AxB3-xO4) are structurally stable for real applications. Much effort has been devoted to improving the catalytic activity. Here, we report a eutectic dealloying strategy to activate the porous spinel NiFe2O4 nanowires with up to four metal cation substitutions. As-obtained spinel NiFeXO4 (X = Fe, Ni, Al, Mo, Co, Cr) delivers a benchmark current density of 10 mA·cm-2 at an overpotential of only 195 mV, outperforming most spinel phase OER electrocatalysts and comparable to the state-of-the-art NiFe hydroxides. It is stable for over 115 h of electrolysis. Aberration-corrected transmission electron microscopy, high-resolution electron energy loss spectroscopy, and atomic-scale strain mappings reveal that the multivalent cation substitutions result in substantial lattice distortion and significant electronic coupling of metal 3d and O 2p orbitals for increased covalency. Further theoretical calculations suggest that the NiFeXO4 are stabilized by the high configurational entropy, and their synergy favors the absorption of H2O molecules and lowers the adsorption energy barrier of the OOH* intermediate. The improved intrinsic activity together with the highly nanoporous structures contribute to the appealing apparent catalytic performances. The work demonstrates an effective approach for the synthesis of stable multicomponent spinel oxides and highlights the effectiveness of the multication substitution strategy for producing highly durable and active spinel catalysts, which meet multiplexed structure and superior property requirements in practical applications.
4 citations
4 citations
TL;DR: In this article , the authors conducted an experimental investigation to explore the influences of spray chamber pressure, mass flow rate and subcooling degree on the cooling capacity on a flat heated surface in a spray cooling cycle using R410A as the working fluid.
3 citations
TL;DR: In this article , a 3D bicontinuous nanoporous Co@CoO/RuO2 composites with tunable sizes and chemical compositions are fabricated by introducing vapor phase dealloying of cobalt-based alloys.
Abstract: The development of low‐cost and effective oxygen evolution reaction (OER) electrocatalysts to expedite the slow kinetics of water splitting is crucial for increasing the efficiency of energy conversion from electricity to hydrogen fuel. Herein, 3D bicontinuous nanoporous Co@CoO/RuO2 composites with tunable sizes and chemical compositions are fabricated by introducing vapor phase dealloying of cobalt‐based alloys. The influence of physical parameters on the formation of nanoporous Co substrates with various feature ligament sizes is systematically investigated. The CoO/RuO2 shell is constructed by integrating a thin layer of RuO2 on the inner surface of nanoporous Co, where the CoO interlayer is formed by annealing oxidization. The composite catalyst delivers an ultralow overpotential of 198 mV at 10 mA cm−2, Tafel slope of 57.1 mV dec−1, and long‐term stability of 50 h. The superior OER activity and fast reaction kinetics are attributed to charge transfer through the coupling of CoORu bonds at the interface and the excellent nanopore connectivity, while the durability originates from the highly stable CoO/RuO2 interface.
3 citations
TL;DR: In this article , the spallation failure of Ni-based single crystal superalloys was studied via non-equilibrium molecular dynamic simulations, and it was shown that the existence of voids significantly lowers the spalation strength, and the amplitude reduction of the strength is directly proportional to the radius of the voids.
2 citations
TL;DR: In this paper , the authors showed that the pump power density is the limiting factor in narrowing the Stokes linewidth of a short-pulse laser, and they used a wide Brillouin gain to obtain a wider range of linewirths.
Abstract: As an effective means to obtain a narrow-linewidth laser, stimulated Brillouin scattering (SBS) has not only the advantages of pulse compression but also controllable Stokes linewidth output. However, most research thus far has been focused on continuous-wave lasers, with little emphasis on short-pulse lasers. This work demonstrates that the Brillouin gain linewidth and pump power density are the primary factors affecting the linewidth of the Stokes pulse. As the pump power density increases, the Stokes linewidth tends to narrow and approaches the pump linewidth. This is the first study to reveal that the pump linewidth is the limiting factor in narrowing the Stokes linewidth. The Stokes linewidths of different liquid media were compared, and it was found that media with a wide Brillouin gain linewidth can be used to obtain lasers with a wider range of linewidths.
2 citations
TL;DR: Wang et al. as discussed by the authors determined the predictors of prolonged viral RNA shedding in patients with non-severe COVID-19 and constructed a nomogram to predict patients at risk of 14-day PCR conversion failure.
Abstract: With the variability in emerging data, guidance on the isolation duration for patients with coronavirus disease 2019 (COVID-19) due to the Omicron variant is controversial. This study aimed to determine the predictors of prolonged viral RNA shedding in patients with non-severe COVID-19 and construct a nomogram to predict patients at risk of 14-day PCR conversion failure.Adult patients with non-severe COVID-19 were enrolled from three hospitals of eastern China in Spring 2022. Viral shedding time (VST) was defined as either the day of the first positive test or the day of symptom onset, whichever was earlier, to the date of the first of two consecutively negative PCR tests. Patients from one hospital (Cohort I, n = 2033) were randomly grouped into training and internal validation sets. Predictors of 14-day PCR conversion failure were identified and a nomogram was developed by multivariable logistic regression using the training dataset. Two hospitals (Cohort II, n = 1596) were used as an external validation set to measure the performance of this nomogram.Of the 2033 patients from Cohort I, the median VST was 13.0 (interquartile range: 10.0‒16.0) days; 716 (35.2%) lasted > 14 days. In the training set, increased age [per 10 years, odds ratio (OR) = 1.29, 95% confidence interval (CI): 1.15‒1.45, P < 0.001] and high Charlson comorbidity index (OR = 1.25, 95% CI: 1.08‒1.46, P = 0.004) were independent risk factors for VST > 14 days, whereas full or boosted vaccination (OR = 0.63, 95% CI: 0.42‒0.95, P = 0.028) and antiviral therapy (OR = 0.56, 95% CI: 0.31‒0.96, P = 0.040) were protective factors. These predictors were used to develop a nomogram to predict VST > 14 days, with an area under the ROC curve (AUC) of 0.73 in the training set (AUC, 0.74 in internal validation set; 0.76 in external validation set).Older age, increasing comorbidities, incomplete vaccinations, and lack of antiviral therapy are risk factors for persistent infection with Omicron variant for > 14 days. A nomogram based on these predictors could be used as a prediction tool to guide treatment and isolation strategies.
2 citations
TL;DR: In this paper , a "hitting three birds with one stone" strategy was reported to prepared boron-doped g-C3N4/TiO2-x composite (BCT) by a one-step thermal reduction process.
Abstract: Using solar energy to drive catalytic conversion of CO2 into value-added chemicals has great potential to alleviate the global energy shortage and anthropogenic climate change. Herein, a "hitting three birds with one stone" strategy was reported to prepared boron-doped g-C3N4/TiO2-x composite (BCT) by a one-step thermal reduction process. A series of characterizations showed that the composite catalyst has extended full-spectrum absorption, rapid photogenerated charge separation, and outstanding CO2 photoreduction performance (265.2 μmol g-1h-1), which is 7.5 and 9.2 times higher than that of pure TiO2 and g-C3N4, respectively. In addition, the CO2 conversion rate can be further increased to 345.1 μmol g-1h-1 at 70 °C due to its excellent photothermal conversion. Mechanistic studies reveal that synergistic effects alter the charge density distribution, thereby lowering the energy barrier for CO2 conversion by adsorbing and activating CO2 molecules. This work provides a novel three-in-one integrated strategy for fabricating high-efficiency catalysts.
2 citations
TL;DR: In this article , the structural and optical properties of semiconductor quantum dots (QDs) were analyzed and illustrated how QDs participate in and facilitate organic reactions belonging to different pathways, and an outlook on the development of QD photocatalysis was presented.
Abstract: Photochemical reactions are among the most important reactions in both theoretical studies and practical applications, since they utilize photon energy as the primary driving force. The sensitizer species is the key component connecting photons and the chemical materials of the reaction, which is conventionally among organic dyes or metal complex molecules. Semiconductor quantum dots (QDs), widely used in optoelectronic materials, and fluorescence sensing can be also applied to organic transformations due to their inherent physical and chemical properties. The similar functionalities and special photophysical features make QDs an ideal sensitizer and promote the efficient progress of the photochemical reactions. Moreover, the booming of QD photocatalysis reveals the excellent potential of interdisciplinary development between nano-materials science and organic chemistry QDs. Hence, a systematical explanation of the reaction principle of QDs in photocatalytic processes is necessary. In this review, we analyze the structural and optical properties of the QDs and illustrate how QDs participate in and facilitate organic reactions belonging to different pathways. We also present an outlook on the development of QD photocatalysis.
TL;DR: In this article , a new method for fabricating high-resolution porous ceramics using the stereolithography 3D printing technology was presented, where polyamide 12 (PA12) powder, alumina ceramic particles, and acrylic resin as the sacrificial porogen, aggregate, and mixture, respectively.
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TL;DR: In this paper , a double-objective global optimal model-free predictive control (MFPC) is proposed based on discrete space vector modulation (DSVM) for surface-mounted permanent magnet synchronous motor (SMPMSM) drive system.
Abstract: To achieve the global optimization of stator current and inverter switching frequency, a double-objective global optimal model-free predictive control (MFPC) is proposed based on discrete space vector modulation (DSVM) for surface-mounted permanent magnet synchronous motor (SMPMSM) drive system. First, the double-objective invalid optimization area of the conventional DSVM-based finite control set (FCS) model predictive control (MPC) is revealed, and the reason is analyzed that the global optimal voltage vector cannot be achieved. Then, according to the distribution of the double-objective invalid optimization area, the voltage hexagon is divided into three subareas. In each subarea, the candidate voltage vector with the best current control performance (BC-CVV) is obtained. Moreover, the inverter switching number of the three BC-CVVs is used as a criterion, and the number of voltage vectors evaluated online is significantly reduced. As a result, the double-objective global optimal voltage vector is achieved without enumerating all the feasible voltage vectors. Finally, experiments under different operating conditions are implemented and the effectiveness of the proposed method is confirmed.
TL;DR: In this article , the authors theoretically and experimentally study the process of SBS in fused silica and examine the energy reflection and pulse compression of input laser pulses as functions of focus position, pump energy and beam diameter.
Abstract: Stimulated Brillouin scattering (SBS) is a non-linear process which has the capacity to improve the beam quality and pulse characteristics of laser beams. In this paper, we theoretically and experimentally study the process of SBS in fused silica. In particular, we examine the energy reflection and pulse compression of input laser pulses as functions of focus position, pump energy and beam diameter. We utilized coupled wave equations and a distributed noise model to simulate the reflected energy and time waveform under different gain parameters. An experimental system is constructed and used to qualify the numerical simulations. The results reveal that the threshold for the SBS process and the energy reflectivity significantly change with laser focus position under the same pump and focusing parameters. Ultimately, the gain characteristics of the SBS material is the primary factor that influences the SBS output. This work presented here offers insight into the operation of short-length solid-state SBS lasers and serves as a basis for the design and optimization of such systems.
TL;DR: In this paper , the levels of 25-hydroxyvitamin D [25(OH)VD] in peripheral blood and vitamin D receptor (VDR) expression in wound margin tissues were measured via chemiluminescence immunoassay, and T-VDR expression level was determined by quantitative realtime PCR.
Abstract: Abstract Background At present, there is no clinical study to elucidate the correlation between vitamin D deficiency and the incidence of diabetic foot osteomyelitis (DFO).This study aims to clarify levels of 25-hydroxyvitamin D [25(OH)VD] in peripheral blood and vitamin D receptor (VDR) expression in wound margin tissues (T-VDR) of patients with type 2 diabetes mellitus (T2DM) with diabetic foot ulcer (DFU) and DFO, and to determine its correlation with treatment outcomes of DFU and DFO, and and its value as a potential biomarker for the diagnosis of DFU and DFO. Methods 156 T2DM patients with DFU (DFU group), 100 T2DM patients without DFU (T2DM group), and 100 healthy controls (NC group). The DFU group patients were subdivided into DFO (n = 80) and NDFO groups (n = 76). The level of serum 25(OH)VD was measured via chemiluminescence immunoassay, and T-VDR expression level was determined by quantitative real-time PCR. Results The levels of serum 25(OH)VD in the DFU group were significantly lower than the T2DM group [(10.3 (5.8, 18.7) vs 15.7 (8.6, 24.6) ng/mL, P = 0.002)]. Similarly, the levels of serum 25(OH)VD and T-VDR expression in the DFO group were statistically lower than the NDFO group [9.2 (5.2, 20.5) vs 12.8 (6.9, 22.1) ng/mL, P = 0.006)], [1.96 (0.61, 3.97) vs 3.11 (1.36, 5.11), P = 0.004)], respectively. Furthermore, the levels of serum 25(OH)VD and T-VDR expression in DFU patients were positively correlated with the ulcer healing rate of foot ulcer after 8 weeks of treatment ( P = 0.031, P = 0.016, respectively). Multivariate logistic regression analysis showed that low level of serum 25(OH)VD was an independent risk factor for DFU and DFO (OR DFU = 2.42, OR DFO = 3.05, P = 0.008, 0.001, respectively), and decreased T-VDR expression level was an independent risk factor for DFO (OR = 2.83, P = 0.004). Meanwhile, the ROC curve analysis indicated that the AUC of serum 25(OH)VD level for the diagnosis of DFU and DFO was 0.821 (95% CI, 0.754–0.886, P < 0.001) and 0.786 (95%CI, 0.643–0.867, P < 0.001), respectively. When establishing a diagnosis of DFO, the AUC of T-VDR expression level was 0.703 (95%CI: 0.618–0.853, P < 0.001). Conclusions The levels of serum 25(OH)VD and T-VDR expression in DFU and DFO decreased. Serum 25(OH)VD and T-VDR are potentially valuable biomarkers for diagnosis and prognosis of DFU and DFO. .
TL;DR: In this article , a shape-memory bio-aerogel with high specific surface areas (up to 220 m2/g) and low radial thermal conductivity (0.042 W/mK) was prepared through a one-step treatment of native wood using an ionic liquid mixture of [MTBD]-[MMP]−/DMSO.
Abstract: Polymer shape-memory aerogels (PSMAs) are prospects in various fields of application ranging from aerospace to biomedicine, as advanced thermal insulators, actuators, or sensors. However, the fabrication of PSMAs with good mechanical performance is challenging and is currently dominated by fossil-based polymers. In this work, strong, shape-memory bio-aerogels with high specific surface areas (up to 220 m2/g) and low radial thermal conductivity (0.042 W/mK) were prepared through a one-step treatment of native wood using an ionic liquid mixture of [MTBD]+[MMP]−/DMSO. The aerogel showed similar chemical composition similar to native wood. Nanoscale spatial rearrangement of wood biopolymers in the cell wall and lumen was achieved, resulting in flexible hydrogels, offering design freedom for subsequent aerogels with intricate geometries. Shape-memory function under stimuli of water was reported. The chemical composition and distribution, morphology, and mechanical performance of the aerogel were carefully studied using confocal Raman spectroscopy, AFM, SAXS/WAXS, NMR, digital image correlation, etc. With its simplicity, sustainability, and the broad range of applicability, the methodology developed for nanoscale reassembly of wood is an advancement for the design of biobased shape-memory aerogels.
TL;DR: Wang et al. as mentioned in this paper explored the underlying mechanism by which KGM induces 5-FU cytotoxicity in HCC cells and showed that KGM combined with 5-Fluorouracil (5-FU) treatment significantly promoted apoptosis and reduced cell proliferation, migration and ER stress.
Abstract: 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for various cancers. However, the drug resistance developed by tumor cells hinders the therapeutic effect. Konjac glucomannan (KGM) is indicated to sensitize 5-FU-resistant hepatocellular carcinoma (HCC) cells to 5-FU. In our study, we found that KGM or 5-FU treatment alone did not affect the malignant cell behaviors and endoplasmic reticulum (ER) stress of 5-FU-resistant HCC cells or HepG2/5-FU and Bel-7402/5-FU cells, while cotreatment with KGM and 5-FU significantly facilitated HCC cell apoptosis and ER stress and suppressed cell proliferation potential and migration abilities. Moreover, we explored the underlying mechanism by which KGM induces 5-FU cytotoxicity in HCC cells. We found that Toll-like receptor 4 (TLR4) was downregulated in KGM- and 5-FU-treated HCC cells. TLR4 overexpression reversed the KGM and 5-FU cotreatment-induced inhibition of the malignant behaviors of 5-FU-resistant HCC cells. Furthermore, KGM enhanced 5-FU-induced ER stress by inhibiting TLR4 to activate PERK/ATF4/CHOP signaling. Xenograft mouse models were established using HepG2/5-FU cells, and KGM was demonstrated to reverse 5-FU resistance in HCC tumors in vivo by suppressing TLR4 to enhance ER stress and activate PERK/ATF4/CHOP signaling. In conclusion, KGM combined with 5-FU treatment significantly promoted apoptosis and reduced cell proliferation, migration and ER stress in 5-FU-resistant HCC cells compared with KGM or 5-FU treatment alone by downregulating TLR4 to activate PERK/ATF4/CHOP signaling.
TL;DR: In this paper , a thermal management system for a Swiss roll-type battery, and the effects of the structural parameters of the Swiss roll BTMS cooling belt, coolant inlet flow rate, and inlet temperature on the heat dissipation performance of the battery module are investigated.
TL;DR: In this article , the authors in situ prepare ZnO microrods in the presence of CNF, which resultes in a layered composite structure, and demonstrate that these composites could be used as physiological motion sensors for human health monitoring.
TL;DR: In this article , an efficient strategy was developed to achieve the fast preparation of organohydrogels by exploring the high reactivity of eutectic gallium-indium alloy in inducing radical polymerization, and constructing the glycerol/water binary solvent system.
Abstract: Currently, developing organohydrogel‐based wearable flexible electronics (WFEs) has aroused intensive research interest, since they possess superior environmental stabilities than hydrogel‐based WFEs, but the development of organohydrogels is still in the infant stage. Herein, an efficient strategy is developed to achieve the fast preparation of organohydrogels by exploring the high reactivity of eutectic gallium–indium alloy in inducing radical polymerization, and constructing the glycerol/water binary solvent system. The obtained organohydrogels, named liquid metal‐based ion‐conducting organohydrogels (LMIOs), possess excellent environmental adaptability over a wide temperature range (−20 to 100 °C) and high transparency. With outstanding mechanical properties and self‐healing abilities, LMIOs can act as strain sensors, showing high sensing sensitivities in broad strain range (0.1–1000%) and fast response speed (<100 ms). Therefore, LMIOs perform well in sensing strains from human motions. Besides, LMIOs can be constructed on latex gloves and prosthetic fingers, forming an LMIO skin on their surfaces. The latex gloves equipped with the LMIO skin can accurately recognize the gesture changes of users. The LMIO skin on the prosthetic finger behaves like human skin, possessing the capability to detect the finger's movements and self‐healing ability. Hence, LMIOs present great prospects in skin‐attachable devices, robotics, and prosthetics.
TL;DR: In this paper , an aluminum-ion battery pack model is accurately built by performing a hybrid pulse power characterization (HPPC) experiment, along with a synchronous regulator converter electric-circuit model of the resistor-capacitor (RC) equivalent circuit.
TL;DR: In this paper , an Ag2O/BiVO4/diatomite composite with p-n heterojunction structure was synthesized by simple hydrothermal method with diatomite as carrier.
TL;DR: In this article , the authors investigated the relationship between early heat anomalies and urban trees' cooling efficiency and found that the 2022 warm spring increased the greenness (reflected by Normalized Difference Vegetation Index-NDVI) of urban trees and advanced urban trees growing stage.
Abstract: India’s heat waves have recently led to huge losses to the natural ecosystem and human society, and are projected to occur earlier and more frequently in the future. Frequent heat waves around the world in recent years highlight the emerging need for heat mitigation in sustainable urban development. Urban greening has been widely recognized as an effective nature-based solution to mitigate thermal stress. However, knowledge of how recent early heat anomalies affect the growth of urban trees and their cooling efficiency (CE) remains unclear. To inform this issue, here we compared the trees’ growth status and CE in 2022 spring heatwave period to that of the same period in 2019–2021 in New Delhi and Haryana, India as a natural experiment, to investigate the relationship between early heat anomalies and urban trees’ CE. Results showed that (1) the 2022 warm spring increased the greenness (reflected by Normalized Difference Vegetation Index-NDVI) of urban trees and advanced urban trees’ growing stage, but more warming effects of urban trees with higher coverage were observed, which is related to the water use. (2) Interannual pattern of the urban trees’ CE in 2022 was different from that of 2019–2021, which is attributed to the changing meteorological variables, i.e., air temperature, precipitation and wind speed from global model Climate Forecast System (CFS), especially the air temperature, and the biophysical responses of trees, using evapotranspiration (ET) as a proxy. We advocate planting more trees in areas with low tree cover percentage, equitable water usage within cities, and more effective thermal mitigation measures are expected to play a sustainable and significant role at the forefront of climate change’s worst impacts. Meanwhile, local trait database and field observation data are essential for the selection of urban trees adaptable and climatically useful in extreme heat events in Indian cities.
TL;DR: In this paper , single crystals of Cr and Fe co-intercalated with the compositions of ${(nb{Nb}{\mathrm{S}}_{2}/{Ta{S})} (x=0.13--0.66$) were successfully grown and their magnetic and transport properties were systematically studied.
Abstract: Recently, many interesting magnetic and electrical properties have been demonstrated in transition-metal intercalated $2\text{H-Nb}{\mathrm{S}}_{2}/\mathrm{Ta}{\mathrm{S}}_{2}$ layered single crystals. In this work, single crystals of Cr and Fe co-intercalated $2\text{H-Nb}{\mathrm{S}}_{2}$, with the compositions of ${({\mathrm{Cr}}_{1--x}{\mathrm{Fe}}_{x})}_{1/3}\mathrm{Nb}{\mathrm{S}}_{2} (x=0.0--1.0)$, are successfully grown and their magnetic and transport properties are systematically studied. With increasing Fe content, the magnetic transition temperature continually decreases from 117 to 37 K, and the magnetic coupling transforms from ferromagnetic to antiferromagnetic. Importantly, a rotation of the magnetic easy axis occurs in this process, with perpendicular magnetocrystalline anisotropy and considerable coercive field achieved in the $x=0.13--0.66$ compounds. Both $x=0.33$ and $x=0.50$ exhibit relatively low carrier concentration, stable anomalous Hall effect, and butterfly-shape magnetoresistance. Notably, large anomalous Hall conductivity is identified in $x=0.50$, whose origin is discussed from the calculated electronic structures. The realization of perpendicular anisotropy and large anomalous Hall conductivity in this two-dimensional ferromagnetic system can facilitate their future application in spintronic devices.
TL;DR: In this article , a two-stage prediction framework is proposed, taking the measurement of the probability density curve and the judgment of ramp-up mode, aiming at the issue of limited prediction information and the sensitivity of prediction values at extreme points.
TL;DR: In this article , the authors focused on four functional urban areas (commercial areas, educational areas, residential areas and wastewater treatment plant) to study the variations in ARG abundances, bacterial community structures and risks to human health during the COVID-19 pandemic in aerosol.
TL;DR: In this article , an intelligent thermosensitive radiopaque nanogel (INCA) was synthesized to achieve complete embolization of arterial trunks and peripheral vessels.
Abstract: ABSTRACT Several vascular embolization materials are commonly used in clinical practice, however, having application defects of varying degrees, such as poor intraoperative imaging and easy recanalization of embolized blood vessels, they are challenging for application during Transcatheter arterial embolization (TAE). Thus, an intraoperative visible vascular embolization material with good embolization effect and biocompatibility can improve transcatheter arterial embolization clinical efficacy to some extent. Our study aimed to synthesize a novel vascular embolization material that can achieve complete embolization of arterial trunks and peripheral vessels, namely poly (N-isopropyl acrylamide)-co-acrylic acid nanogel (NIPAM-co-AA). Iohexol 200 mg/mL was co-assembled with 7 wt% NIPAM-co-AA nanogel to create an intelligent thermosensitive radiopaque nanogel (INCA), which achieves a good intraoperative imaging effect and is convenient for transcatheter arterial bolus injection due to its good fluidity and temperature-sensitive sol-gel phase transition. The normal rabbit kidney embolism model further confirmed that INCA could effectively use Digital subtraction angiography (DSA) to achieve intraoperative imaging, and real-time monitoring of the embolization process could avoid mis-embolization and leakage. Meanwhile, in a 42-day study, INCA demonstrated an excellent embolization effect on the right renal artery of New Zealand white rabbits, with no vascular recanalization and ischemic necrosis and calcification remaining. As a result, this radiopaque thermosensitive nanogel has the potential to be an intelligent thermosensitive medical vascular embolization material, providing dual benefits in TAE intraoperative imaging and long-term postoperative embolization while effectively addressing the shortcomings and challenges of commonly used clinical vascular embolization agents.