M
Mingyi Xie
Researcher at University of Florida
Publications - 36
Citations - 3039
Mingyi Xie is an academic researcher from University of Florida. The author has contributed to research in topics: RNA & microRNA. The author has an hindex of 15, co-authored 28 publications receiving 2601 citations. Previous affiliations of Mingyi Xie include Yale University & Arizona State University.
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Journal ArticleDOI
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Mary Armanios,Julian J.-L. Chen,Joy D. Cogan,Jonathan K. Alder,Roxann G. Ingersoll,Cheryl Markin,William Lawson,William Lawson,Mingyi Xie,Irma Vulto,John A. Phillips,Peter M. Lansdorp,Carol W. Greider,James E. Loyd +13 more
TL;DR: In this paper, the authors found that mutations in the genes encoding telomerase components can appear as familial idiopathic pulmonary fibrosis, which is a rare hereditary disorder associated with premature death from aplastic anemia and lung fibrosis.
Journal ArticleDOI
Short telomeres are a risk factor for idiopathic pulmonary fibrosis
Jonathan K. Alder,Julian J.-L. Chen,Lisa Lancaster,Sonye K. Danoff,Shu Chih Su,Joy D. Cogan,Irma Vulto,Mingyi Xie,Xiaodong Qi,Rubin M. Tuder,John A. Phillips,Peter M. Lansdorp,James E. Loyd,Mary Armanios +13 more
TL;DR: Short telomeres are a signature in IIPs and likely play a role in their age-related onset, and the clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver.
Journal ArticleDOI
Mammalian 5′-Capped MicroRNA Precursors that Generate a Single MicroRNA
Mingyi Xie,Mingfeng Li,Anna Vilborg,Nara Lee,Mei-Di Shu,Valeria Yartseva,Nenad Sestan,Joan A. Steitz +7 more
TL;DR: This unusual miRNA biogenesis pathway, which differs in pre-miRNA synthesis, nuclear-cytoplasmic transport, and guide strand selection, enables the development of shRNA expression constructs that produce a single 3p-siRNA.
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Viral noncoding RNAs: more surprises
Kazimierz T. Tycowski,Yang Eric Guo,Nara Lee,Walter N. Moss,Tenaya K. Vallery,Mingyi Xie,Joan A. Steitz +6 more
TL;DR: This review focuses on the multitude of functions played by ncRNAs produced by animal viruses, and discusses their biogenesis and mechanisms of action.
Journal ArticleDOI
A Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs
TL;DR: Deep sequencing identified six HVS microRNAs (miRNAs) that are derived from three hairpin structures located immediately downstream of the 3' end processing signals of three of the HSURs that are linked by identifying chimeric HSUR-pre-miRNA transcripts.