J
Joy D. Cogan
Researcher at Vanderbilt University Medical Center
Publications - 109
Citations - 7741
Joy D. Cogan is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 41, co-authored 95 publications receiving 6593 citations. Previous affiliations of Joy D. Cogan include Vanderbilt University.
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Journal ArticleDOI
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Mary Armanios,Julian J.-L. Chen,Joy D. Cogan,Jonathan K. Alder,Roxann G. Ingersoll,Cheryl Markin,William Lawson,William Lawson,Mingyi Xie,Irma Vulto,John A. Phillips,Peter M. Lansdorp,Carol W. Greider,James E. Loyd +13 more
TL;DR: In this paper, the authors found that mutations in the genes encoding telomerase components can appear as familial idiopathic pulmonary fibrosis, which is a rare hereditary disorder associated with premature death from aplastic anemia and lung fibrosis.
Journal ArticleDOI
Short telomeres are a risk factor for idiopathic pulmonary fibrosis
Jonathan K. Alder,Julian J.-L. Chen,Lisa Lancaster,Sonye K. Danoff,Shu Chih Su,Joy D. Cogan,Irma Vulto,Mingyi Xie,Xiaodong Qi,Rubin M. Tuder,John A. Phillips,Peter M. Lansdorp,James E. Loyd,Mary Armanios +13 more
TL;DR: Short telomeres are a signature in IIPs and likely play a role in their age-related onset, and the clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
Tasha E. Fingerlin,Elissa Murphy,Weiming Zhang,Anna L. Peljto,Kevin K. Brown,Mark P. Steele,James E. Loyd,Gregory P. Cosgrove,David A. Lynch,Steve D. Groshong,Harold R. Collard,Paul J. Wolters,Williamson Z. Bradford,Karl Kossen,Scott D. Seiwert,Roland M. du Bois,Christine Kim Garcia,Megan S. Devine,Gunnar Gudmundsson,Helgi J Isaksson,Naftali Kaminski,Yingze Zhang,Kevin F. Gibson,Lisa Lancaster,Joy D. Cogan,Wendi R. Mason,Toby M. Maher,Philip L. Molyneaux,Athol U. Wells,Miriam F. Moffatt,Moisés Selman,Annie Pardo,Dong Soon Kim,James D. Crapo,Barry J. Make,Elizabeth A. Regan,Dinesha Walek,Jerry Daniel,Yoichiro Kamatani,Diana Zelenika,Keith P Smith,David McKean,Brent S. Pedersen,Janet Talbert,Ravin N. Kidd,Cheryl Markin,Kenneth B. Beckman,Mark Lathrop,Mark Lathrop,Marvin I. Schwarz,David A. Schwartz +50 more
TL;DR: The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Journal ArticleDOI
Mutations in PROP1 cause familial combined pituitary hormone deficiency
Wei Wu,Joy D. Cogan,Roland Pfäffle,Jeremy S. Dasen,Herwig Frisch,Shawn M. O'Connell,Sarah E. Flynn,Milton R. Brown,Primus E. Mullis,John S. Parks,John A. Phillips,Michael G. Rosenfeld +11 more
TL;DR: The results identify a major cause of CPHD in humans and suggest a direct or indirect role for PROP1 in the ontogenesis of pituitary gonadotropes, as well as somatotrope, lactotropes and caudomedial thyrotropes.
Journal ArticleDOI
Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females.
Eric D. Austin,Joy D. Cogan,James West,Lora K. Hedges,Rizwan Hamid,Elliott P. Dawson,Lisa Wheeler,F. F. Parl,James E. Loyd,John A. Phillips +9 more
TL;DR: Variations in oestrogens and oestrogen metabolism modify FPAH risk, and gene expression data implicating the oest estrogen-metabolising enzyme CYP1B1 suggests a detrimental role.