Miren Maicas

TL;DR: It is shown that transcription factors operate as terminal selectors in distinct combinations in different neuron types, defining neuron type-specific identity features.

TL;DR: The cis-regulatory transcriptional code that controls the differentiation of serotonergic HSN neurons in Caenorhabditis elegans is identified and rules governing the regulatory landscape of a critically important neuronal type in two species separated by over 700 million years are identified.

TL;DR: It is found that patients with no basal expression of EVI1 had a better prognosis than patients with expression/over-expression, and it is demonstrated for the first time that an aberrant epigenetic pattern involving DNA methylation, H3 and H4 acetylation, and trimethylation might play a role in the transcriptional regulation of EVsI1 in acute myeloid leukemia.

TL;DR: The hypothesis that induced EVI1 expression in a murine model silences hsa-miR-124 expression by DNA methylation is supported, although they would also indicate that, in some cases, the expression of hSA-mi R-124 might be regulated by other mechanisms.

TL;DR: The data showed that EVI1 controls proliferation in AML through modulation of miR-1-2 andmiR-133-a-1 in established cell lines and in patient samples, and confirmed thatEVI1 binds directly to the promoter of these two miRNAs.