J
Jose Roman-Gomez
Researcher at Sofia University
Publications - 62
Citations - 4928
Jose Roman-Gomez is an academic researcher from Sofia University. The author has contributed to research in topics: DNA methylation & Leukemia. The author has an hindex of 43, co-authored 62 publications receiving 4646 citations.
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Epigenetic regulation of microRNA expression in colorectal cancer
Eva Bandrés,Xabier Agirre,Nerea Bitarte,Natalia Ramírez,Ruth Zarate,Jose Roman-Gomez,Felipe Prosper,Jesús García-Foncillas +7 more
TL;DR: The results aid in the understanding of miRNA gene regulation showing that aberrant DNA methylation and histone modifications work together to induce silencing of miRNAs in CRC.
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Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia
Xabier Agirre,Amaia Vilas-Zornoza,Antonio Jiménez-Velasco,José I. Martín-Subero,Lucia Cordeu,Leire Garate,Edurne San José-Enériz,Gloria Abizanda,Paula Rodriguez-Otero,Puri Fortes,José Rifón,Eva Bandrés,María José Calasanz,Vanesa Martín,Anabel Heiniger,Antoni Torres,Reiner Siebert,Jose Roman-Gomez,Felipe Prosper +18 more
TL;DR: The methylation and chromatin status of the miR-124a loci in ALL provided the grounds for new therapeutic strategies in ALL either targeting the epigenetic regulation of microRNAs and/or directly targeting the CDK6-Rb pathway.
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Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia
Jose Roman-Gomez,Antonio Jiménez-Velasco,Xabier Agirre,Francisco Cervantes,Joaquín Sánchez,Leire Garate,Manuel Barrios,Juan A. Castillejo,German Navarro,Dolors Colomer,Felipe Prosper,Anabel Heiniger,Antoni Torres +12 more
TL;DR: It is suggested that activation of both sense and antisense transcriptions by aberrant promoter hypomethylation of the L1 elements plays a role in the progression and clinical behavior of the CML.
Journal ArticleDOI
Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia.
Jose Roman-Gomez,Antonio Jiménez-Velasco,Juan A. Castillejo,Xabier Agirre,Manuel Barrios,German Navarro,Francisco Molina,María José Calasanz,Felipe Prosper,Anabel Heiniger,Antoni Torres +10 more
TL;DR: The methylation profile may be a potential new biomarker of risk prediction in ALL and was an independent prognostic factor in predicting DFS and OS at 11 years.
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Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth.
Xabier Agirre,Antonio Jiménez-Velasco,Edurne San José-Enériz,Leire Garate,Eva Bandrés,Lucia Cordeu,Oscar Aparicio,Borja Saez,German Navarro,Amaia Vilas-Zornoza,Ignacio Pérez-Roger,Jesús García-Foncillas,Antoni Torres,Anabel Heiniger,María José Calasanz,Puri Fortes,Jose Roman-Gomez,Felipe Prosper +17 more
TL;DR: The results indicate that down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of CML implicating a miRNA in the abnormal behavior of C ML.