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Richard S. Mann
Researcher at Columbia University
Publications - 172
Citations - 18325
Richard S. Mann is an academic researcher from Columbia University. The author has contributed to research in topics: Hox gene & Transcription factor. The author has an hindex of 63, co-authored 164 publications receiving 16652 citations. Previous affiliations of Richard S. Mann include Massachusetts Institute of Technology & Stanford University.
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Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus
TL;DR: PMOV-psi- has a defect in the packaging of genomic RNA into virions but can provide in trans the products necessary for virion production, and can be used to produce helper-free stocks of natural or synthetic defective retroviruses.
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The role of DNA shape in protein–DNA recognition
TL;DR: These findings indicate that the ability to detect local variations in DNA shape and electrostatic potential is a general mechanism that enables proteins to use information in the minor groove, which otherwise offers few opportunities for the formation of base-specific hydrogen bonds, to achieve DNA-binding specificity.
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Origins of Specificity in Protein-DNA Recognition
TL;DR: This review provides a revised view of protein-DNA interactions that emphasizes the importance of the three-dimensional structures of both macromolecules and argues that individual DNA-binding proteins combine multiple readout mechanisms to achieve DNA- binding specificity.
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Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms.
Matthew B. Bouchard,Venkatakaushik Voleti,César S. Mendes,Clay Lacefield,Wesley B. Grueber,Richard S. Mann,Randy M. Bruno,Elizabeth M. C. Hillman +7 more
TL;DR: A new 3D microscopy technique that allows volumetric imaging of living samples at ultra-high speeds: Swept, confocally-aligned planar excitation (SCAPE) microscopy, demonstrated by imaging spontaneous neuronal firing in the intact brain of awake behaving mice, as well as freely moving transgenic Drosophila larvae.
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Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
Helke Pöpperl,Mariann Bienz,Michèle Studer,Siu-Kwong Chan,Samuel Aparicio,Sydney Brenner,Richard S. Mann,Robb Krumlauf +7 more
TL;DR: In vivo and in vitro evidence is provided that r4 expression involves direct autoregulation dependent on cooperative interactions of Hoxb-1 with exd/pbx proteins as cofactors.