M
Mitsutaka Yamamoto
Researcher at Rutgers University
Publications - 6
Citations - 479
Mitsutaka Yamamoto is an academic researcher from Rutgers University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 3 publications receiving 463 citations. Previous affiliations of Mitsutaka Yamamoto include University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Mitsutaka Yamamoto,Guiping Yang,Chull Hong,Jing Liu,Eric Holle,Xianzhong Yu,Thomas E. Wagner,Stephen F. Vatner,Junichi Sadoshima +8 more
TL;DR: It is demonstrated that endogenous Trx1 is an essential component of the cellular antioxidant mechanisms and plays a critical role in regulating oxidative stress in the heart in vivo and inhibits hypertrophy, both under basal conditions and in response to pressure overload through redox-sensitive mechanisms.
Journal ArticleDOI
Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice
Peiyong Zhai,Mitsutaka Yamamoto,Jonathan Galeotti,Jing Liu,Malthi Masurekar,Jill Thaisz,Keiichi Irie,Eric Holle,Xianzhong Yu,Sabina Kupershmidt,Dan M. Roden,Thomas Wagner,Atsuko Yatani,Dorothy E. Vatner,Stephen F. Vatner,Junichi Sadoshima +15 more
TL;DR: The AT1 receptor mediates downstream signaling mechanisms through G( alpha)q/G(alpha)i-dependent and -independent mechanisms, which induce hypertrophy with a distinct phenotype in Tg-i2m mice.
Journal ArticleDOI
Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart.
Tetsuro Ago,Ijen Yeh,Mitsutaka Yamamoto,Martina Schinke-Braun,Jeffrey A. Brown,Bin Tian,Junichi Sadoshima +6 more
TL;DR: The results suggest that, in cardiac myocytes, Trx1 upregulates mitochondrial proteins and enhances mitochondrial functions, possibly through PGC-1alpha and NRFs.
Journal ArticleDOI
Association between Serum Oxysterols and Coronary Plaque Regression during Lipid-Lowering Therapy with Statin and Ezetimibe: Insights from the CuVIC Trial.
Yasuhiro Nakano,Mitsutaka Yamamoto,Tetsuya Matoba,Shun Katsuki,Soichi Nakashiro,Susumu Takase,Yusuke Akiyama,Takuya Nagata,Yasushi Mukai,Shujiro Inoue,Keiji Oi,Taiki Higo,Masao Takemoto,Nobuhiro Suematsu,Kenichi Eshima,Kenji Miyata,Makoto Usui,Kenji Sadamatsu,Toshiaki Kadokami,Kiyoshi Hironaga,Ikuyo Ichi,Koji Todaka,Junji Kishimoto,Hiroyuki Tsutsui +23 more
TL;DR: In this article , the authors conducted a prospective IVUS analysis in a subgroup from the CuVIC trial and found that ezetimibe in combination with statin achieved significantly lower LDL-C, campesterol, and 27-hydroxycholesterol, which resulted in greater coronary plaque regression.
Journal ArticleDOI
Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis
Yusuke Akiyama,Shun Katsuki,Tetsuya Matoba,Yasuhiro Nakano,Susumu Takase,Soichi Nakashiro,Mitsutaka Yamamoto,Yasushi Mukai,Shujiro Inoue,Keiji Oi,Taiki Higo,Masao Takemoto,Nobuhiro Suematsu,Kenichi Eshima,Kenji Miyata,Makoto Usui,Kenji Sadamatsu,Toshiaki Kadokami,Kiyoshi Hironaga,Ikuyo Ichi,Koji Todaka,Junji Kishimoto,Hiroyuki Tsutsui +22 more
TL;DR: The relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease was investigated in this article , where subjects who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally.