M
Miwako Tanaka
Researcher at Hiroshima University
Publications - 12
Citations - 579
Miwako Tanaka is an academic researcher from Hiroshima University. The author has contributed to research in topics: Lymphangiogenesis & Metastasis. The author has an hindex of 7, co-authored 12 publications receiving 544 citations.
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Journal ArticleDOI
Mesenchymal stem cells enhance growth and metastasis of colon cancer.
Kei Shinagawa,Yasuhiko Kitadai,Miwako Tanaka,Tomonori Sumida,Michiyo Kodama,Yukihito Higashi,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +8 more
TL;DR: Collectively, MSCs migrate and differentiate into CAFs in tumor stroma, and they promote growth and metastasis of colon cancer by enhancing angiogenesis, migration and invasion and by inhibiting apoptosis of tumor cells.
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Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma.
Michiyo Kodama,Yasuhiko Kitadai,Tomonori Sumida,Mayu Ohnishi,Eiji Ohara,Miwako Tanaka,Kei Shinagawa,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +9 more
TL;DR: The data indicate that secretion of PDGF‐B by gastric carcinoma cells and expression ofPDGF‐Rβ by tumor‐associated stromal cells are associated with lymphatic metastasis.
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Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms.
Michiyo Kodama,Yasuhiko Kitadai,Miwako Tanaka,Toshio Kuwai,Shinji Tanaka,Naohide Oue,Wataru Yasui,Kazuaki Chayama +7 more
TL;DR: VEGF-C may play a role in the progressive growth of human gastric carcinoma through both autocrine and paracrine mechanisms.
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Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
Kei Shinagawa,Yasuhiko Kitadai,Miwako Tanaka,Tomonori Sumida,Mieko Onoyama,Mayu Ohnishi,Eiji Ohara,Yukihito Higashi,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +10 more
TL;DR: The data suggest that blockade of PDGF signaling pathways influences the interaction between bone marrow‐derived MSCs and tumor cells in the tumor microenvironment and, hence, inhibits the progressive growth of colon cancer.
Journal ArticleDOI
Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model.
Tomonori Sumida,Yasuhiko Kitadai,Kei Shinagawa,Miwako Tanaka,Michiyo Kodama,Mayu Ohnishi,Eiji Ohara,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +9 more
TL;DR: Administration of PDGF‐R tyrosine kinase inhibitor in combination with irinotecan appears to impair the progressive growth of gastric carcinoma by blockade of PD GF‐R signaling pathways in stromal cells.