Miyuki Namatame

TL;DR: Three novel antitrypanosomal alkaloids were isolated by silica gel column chromatography and HPLC from the culture broth of a new endophytic actinomycete species and shown to be new types of pyochelin family antibiotic.

TL;DR: Ethyl acetate extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum, and six flavonoids, lupinifolin, citflavanone, erythrisenegalone, lonchocarpol A, and 8-prenyldaidzein were isolated from the extract.

TL;DR: This is the first report of antitrypanosomal activities of the 10 microbial metabolites listed above, and it is confirmed that these compounds are selective and potent against African trypanosomes.

TL;DR: This finding represents the first report of promising trypanocidal activity of these terpenes and provides some valuable insight with regard to structure-activity relationships and the possible mode of action of the compounds.

TL;DR: Puberulic acid demonstrated a therapeutic effect in vivo, which compared well against the currently used antimalarial drugs, and thus shows promise as a leading candidate for development into a new antimalaria compound.