T
Toshihiro Hashimoto
Researcher at Tokushima Bunri University
Publications - 252
Citations - 6756
Toshihiro Hashimoto is an academic researcher from Tokushima Bunri University. The author has contributed to research in topics: Aspergillus niger & Cytotoxic T cell. The author has an hindex of 42, co-authored 252 publications receiving 6278 citations. Previous affiliations of Toshihiro Hashimoto include Korean Council for University Education & Tamkang University.
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Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2.
Takashi Oshima,Masahiro Abe,Jin Asano,Tomoko Hara,Kenichi Kitazoe,Etsuko Sekimoto,Yoichi Tanaka,Hironobu Shibata,Toshihiro Hashimoto,Shuji Ozaki,Shinsuke Kido,Daisuke Inoue,Toshio Matsumoto +12 more
TL;DR: In addition to enhanced osteolysis, MM cells also suppress bone formation at least in part through an inhibition of the canonical Wnt pathway by secreting sFRP-2, suggesting a predominant role for MM cell-derived sFRp-2 in the impairment of bone formation by MM.
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Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion.
Masahiro Abe,Kenji Hiura,Javier Wilde,Atsushi Shioyasono,Keiji Moriyama,Toshihiro Hashimoto,Shinsuke Kido,Takashi Oshima,Hironobu Shibata,Shuji Ozaki,Daisuke Inoue,Toshio Matsumoto +11 more
TL;DR: It is demonstrated that peripheral blood mononuclear cell-derived OCs enhanced growth and survival of primary MM cells as well as MM cell lines more potently than stromal cells, and that OCs protected MM cells from apoptosis induced by serum depletion or doxorubicin.
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Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma
Masahiro Abe,Kenji Hiura,Javier Wilde,Keiji Moriyama,Toshihiro Hashimoto,Shuji Ozaki,Shingo Wakatsuki,Masaaki Kosaka,Shinsuke Kido,Daisuke Inoue,Toshio Matsumoto +10 more
TL;DR: Results suggest that MIP-1α and Mip-1β may be major osteoclast-activating factors produced by MM cells, and C-C chemokines, macrophage inflammatory protein (MIP)–1 α and MIP -1β, in MM cell-induced osteolysis.
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Myeloma Cell-Osteoclast Interaction Enhances Angiogenesis Together with Bone Resorption: A Role for Vascular Endothelial Cell Growth Factor and Osteopontin
Yoichi Tanaka,Masahiro Abe,Masahiro Hiasa,Asuka Oda,Hiroe Amou,Ayako Nakano,Kyoko Takeuchi,Kenichi Kitazoe,Shinsuke Kido,Daisuke Inoue,Keiji Moriyama,Toshihiro Hashimoto,Shuji Ozaki,Toshio Matsumoto +13 more
TL;DR: Osteoclast-derived osteopontin and VEGF from myeloma cells cooperatively enhance angiogenesis and also induce osteoclastogenic activity by vascular endothelial cells, suggesting the presence of a close link between myelomas cells, osteoclasts, and vascular endothelium cells to form a vicious cycle between bone destruction, angiogenic, and myelomatic expansion.
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CD36- and GPR120-Mediated Ca2+ Signaling in Human Taste Bud Cells Mediates Differential Responses to Fatty Acids and Is Altered in Obese Mice
Mehmet Hakan Ozdener,Selvakumar Subramaniam,Sinju Sundaresan,Omar Sery,Toshihiro Hashimoto,Yoshinori Asakawa,Philippe Besnard,Nada A. Abumrad,Naim Akhtar Khan +8 more
TL;DR: CD36 and GPR120 have nonoverlapping roles in TBC signaling during orogustatory perception of dietary lipids; these are differentially regulated by obesity.