M
Mohamed A. Alfaleh
Researcher at King Abdulaziz University
Publications - 44
Citations - 764
Mohamed A. Alfaleh is an academic researcher from King Abdulaziz University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 29 publications receiving 338 citations. Previous affiliations of Mohamed A. Alfaleh include University of Queensland.
Papers
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Journal ArticleDOI
Phage Display Derived Monoclonal Antibodies: From Bench to Bedside.
Mohamed A. Alfaleh,Hashem O. Alsaab,Ahmad Bakur Mahmoud,Almohanad A. Alkayyal,Martina L. Jones,Stephen M. Mahler,Anwar M. Hashem +6 more
TL;DR: The utility of phage display as a powerful platform for therapeutic antibodies discovery is illustrated and all the approved mAbs derived fromphage display are described.
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Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review.
Anwar M. Hashem,Badrah S. Alghamdi,Abdullah Algaissi,Abdullah Algaissi,Fahad S. Alshehri,Abdullah Bukhari,Mohamed A. Alfaleh,Ziad A. Memish +7 more
TL;DR: It is worth being mindful of the potential risks and strictly rational the use of these drugs in COVID-19 patients until further high quality randomized clinical trials are available to clarify their role in the treatment or prevention of CO VID-19.
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SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients
Abdullah Algaissi,Abdullah Algaissi,Mohamed A. Alfaleh,Sharif Hala,Sharif Hala,Turki S. Abujamel,Sawsan S. Al-amri,Sarah A Almahboub,Khalid A Alluhaybi,Haya I. Hobani,Reem M. Alsulaiman,Rahaf H. Alharbi,M-Z Aki ElAssouli,Rowa Y. Alhabbab,Ahdab AlSaieedi,Wesam H. Abdulaal,Afrah Alsomali,Fadwa S. Alofi,Asim Khogeer,Almohanad A. Alkayyal,Ahmad Bakur Mahmoud,Naif A.M. Almontashiri,Arnab Pain,Arnab Pain,Arnab Pain,Anwar M. Hashem +25 more
TL;DR: Serological testing of antibody response in COVID-19 patients suggests that the inclusion of both S1 and N in serological testing would capture as many potential SARS-CoV-2 positive cases as possible than using any of them alone.
Journal ArticleDOI
Targeting membrane proteins for antibody discovery using phage display.
Martina L. Jones,Mohamed A. Alfaleh,Mohamed A. Alfaleh,Sumukh Kumble,Shuo Zhang,Geoffrey W. Osborne,Michael Yeh,Neetika Arora,Jeff Jia Cheng Hou,Christopher B. Howard,David Y. Chin,Stephen M. Mahler +11 more
TL;DR: The successful isolation of antibodies from a naive scFv library is described for three membrane bound proteins; human CD83, canine CD117 and bat CD11b.
Journal ArticleDOI
Formulation Design, Statistical Optimization, and In Vitro Evaluation of a Naringenin Nanoemulsion to Enhance Apoptotic Activity in A549 Lung Cancer Cells.
Shadab,Nabil A. Alhakamy,Hibah M. Aldawsari,Mohammad Husain,Sabna Kotta,Samaa T Abdullah,Usama A. Fahmy,Mohamed A. Alfaleh,Hani Z. Asfour +8 more
TL;DR: Stable naringenin nanoemulsions were more effective than the NAR solution in reducing Bcl2 expression, while increasing pro-apoptotic Bax and caspase-3 activity and could be a suitable drug delivery system to enhance the effects of NAR in the treatment of lung cancer.