Mohammad Amin Moradi

TL;DR: CryoTEM is utilized to provide an essential insight into the role of structure evolution in materials synthesis by combining the information on what is possible in nature and by focusing on a limited number of chemical components.

TL;DR: In this article, a short polypeptide consisting of 3 lysines was used to conduct RAFT dispersion polymerization of 2-hydroxypropyl methacrylate (HPMA) in water at 60 °C.

TL;DR: Hepatic RES targeting requires just a single lipid change within the formulation of Onpattro to switch LNP surface charge from neutral to anionic, and exemplifies that rational design of advanced RNA therapies must be preceded by a robust understanding of the dominant nano–biointeractions involved.

TL;DR: Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size and subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle crosslinking through disulfide bond formation accompanied by the shrinkage of the particles.

TL;DR: In this paper, native chemical ligation (NCL) was used as a selective cross-linking method to form core-crosslinked thermosensitive polymeric micelles for drug delivery applications.