Mohammad Zia-Ebrahimi

TL;DR: A potent, selective, small-molecule FGFR inhibitor, designated as LY2874455, that exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF-FGFR relevant tumor histologies.

TL;DR: The first total synthesis of lipid II is reported, the final monomeric intermediate utilized by Gram positive bacteria for peptidoglycan biosynthesis, in an effort to address the issue of securing useful quantities of their requisite substrates from natural substrates.

TL;DR: In this article, the use of 4-substituted pyrimidine derivatives as mGluR1 antagonists was discussed. But the main focus of the present paper was on the synthesis of a process for the preparation of 4 -substantially modified pyridine derivatives.

TL;DR: A total synthesis of lipid I, a membrane-associated intermediate in the bacterial cell wall (peptidoglycan) biosynthesis pathway, is reported, which will enable further studies on bacterial resistance mechanisms and may provide insight toward the development of new chemotherapeutic agents with novel modes of action.