M
Mohd Shariq
Researcher at Indian Council of Medical Research
Publications - 5
Citations - 74
Mohd Shariq is an academic researcher from Indian Council of Medical Research. The author has contributed to research in topics: Autophagy & Innate immune system. The author has an hindex of 2, co-authored 5 publications receiving 10 citations.
Papers
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Journal ArticleDOI
Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation.
Mohd Shariq,Neha Quadir,Neha Quadir,Neha Sharma,Neha Sharma,Jasdeep Singh,Javaid A. Sheikh,Mohd Khubaib,Seyed E. Hasnain,Seyed E. Hasnain,Seyed E. Hasnain,Nasreen Z. Ehtesham +11 more
TL;DR: RipA (Rv1477), a peptidoglycan hydrolase, has been shown to activate the NFκB signaling pathway and elicits the production of pro-inflammatory cytokines, TNF-α, IL-6, and IL-12, through the activation of an innate immune-receptor, toll-like receptor (TLR)4 as mentioned in this paper.
Journal ArticleDOI
Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival.
Neha Sharma,Neha Sharma,Mohd Shariq,Neha Quadir,Neha Quadir,Jasdeep Singh,Javaid A. Sheikh,Seyed E. Hasnain,Seyed E. Hasnain,Nasreen Z. Ehtesham +9 more
TL;DR: In this article, the authors show that PE6 protein (Rv0335c) is a secretory protein effector that interacts with TLR4 on the macrophage cell surface and promotes activation of the canonical NF-B signaling pathway to stimulate secretion of proinflammatory cytokines TNF-α, IL-12, and IL-6.
Journal ArticleDOI
Teleological cooption of Mycobacterium tuberculosis PE/PPE proteins as porins: Role in molecular immigration and emigration.
Aquib Ehtram,Mohd Shariq,Sabeeha Ali,Neha Quadir,Javaid A. Sheikh,Faraz Ahmad,Tarina Sharma,Nasreen Z. Ehtesham,Seyed E. Hasnain,Seyed E. Hasnain +9 more
TL;DR: In this paper, the authors have discussed recent evidence supporting PE/PPE's role as a specific transport channel for selective uptake of small molecule nutrients and, as possible molecular export machinery of M. tuberculosis (M. tb).
Journal ArticleDOI
Post translational modifications in tuberculosis: ubiquitination paradox
Mohd Shariq,Neha Quadir,Neha Quadir,Javaid A. Sheikh,Alok Kumar Singh,William R. Bishai,Nasreen Z. Ehtesham,Seyed Ehtesham Hasnain +7 more
TL;DR: The co-option of the ubiquitin pathway by the M. tb virulence effectors is discussed and the role of autophagy receptors in this co-optation is discussed.
Book ChapterDOI
Exploration of the Mycobacterial Proteome in the Pathogenesis of TB: A Perspective
Mohd Shariq,Sheeba Zarin,Nilisha Rastogi,Indu Kumari,Farha Naz,Tarina Sharma,Neha Sharma,Nasreen Z. Ehtesham +7 more
TL;DR: Protein profiling of different strains of mycobacteria, clinically relevant, as well as drug-resistant isolates, has tremendously increased our knowledge in the understanding of disease mechanism as discussed by the authors.