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William R. Bishai
Researcher at Johns Hopkins University
Publications - 354
Citations - 21710
William R. Bishai is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 78, co-authored 332 publications receiving 19735 citations. Previous affiliations of William R. Bishai include J. Craig Venter Institute & Duke University.
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Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat.
TL;DR: The characteristics of these new strains of community-acquired MRSA that have contributed to their pathogenicity are reviewed and new approaches to the diagnosis and management of suspected and confirmed community- acquired MRSA infections are discussed.
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Whole-Genome Comparison of Mycobacterium tuberculosis Clinical and Laboratory Strains
Robert D. Fleischmann,David Alland,Jonathan A. Eisen,L. Carpenter,Owen White,Jeremy Peterson,Robert T. DeBoy,Robert J. Dodson,Michelle L. Gwinn,Daniel H. Haft,Erin Hickey,James F. Kolonay,William C. Nelson,Lowell Umayam,Maria D. Ermolaeva,Steven L. Salzberg,Arthur L. Delcher,T. Utterback,Janice Weidman,Hoda Khouri,John Gill,A. Mikula,William R. Bishai,William R. Jacobs,J. C. Venter,Claire M. Fraser +25 more
TL;DR: Results demonstrate that polymorphisms among M. tuberculosis strains are more extensive than initially anticipated, and genetic variation may have an important role in disease pathogenesis and immunity.
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Diagnostic point-of-care tests in resource-limited settings
Paul K. Drain,Emily P. Hyle,Farzad Noubary,Farzad Noubary,Farzad Noubary,Kenneth A. Freedberg,Douglas Wilson,William R. Bishai,William Rodriguez,Ingrid V. Bassett +9 more
TL;DR: A framework for the assessment of point-of-care tests is proposed, and the term test efficacy is suggested to describe the ability of a diagnostic test to support a clinical decision within its operational context, and revised criteria for an ideal diagnostic point- of-care test in resource-limited settings are proposed.
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Mechanisms of latency in Mycobacterium tuberculosis
TL;DR: The mechanisms by which M. tuberculosis establishes a latent metabolic state, eludes immune surveillance and responds to triggers that stimulate reactivation are a high priority for the future control of TB.
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Fluoroquinolones, tuberculosis, and resistance
TL;DR: There is concern about the development of fluoroquinolone resistance in Mycobacterium tuberculosis, particularly when administered as monotherapy or as the only active agent in a failing multidrug regimen.