M
Moien Kanaan
Researcher at Bethlehem University
Publications - 57
Citations - 3134
Moien Kanaan is an academic researcher from Bethlehem University. The author has contributed to research in topics: Hearing loss & Population. The author has an hindex of 29, co-authored 56 publications receiving 2869 citations. Previous affiliations of Moien Kanaan include University of Arizona & Ohio State University.
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Journal ArticleDOI
A novel deletion involving the connexin-30 gene, del(GJB6-d13s1854), found in trans with mutations in the GJB2 gene (connexin-26) in subjects with DFNB1 non-syndromic hearing impairment
F J del Castillo,Montserrat Rodríguez-Ballesteros,Araceli Álvarez,Hutchin Tp,Emanuela Leonardi,C. A. M. de Oliveira,Hela Azaiez,Zippora Brownstein,Matthew R. Avenarius,Sandrine Marlin,Arti Pandya,Hashem Shahin,Kirby Siemering,Dominique Weil,Wim Wuyts,Luis A. Aguirre,Y. Martin,M A Moreno-Pelayo,Manuela Villamar,Karen B. Avraham,H.-H. M. Dahl,Moien Kanaan,Walter E. Nance,Christine Petit,Richard J.H. Smith,G. Van Camp,Edi Lúcia Sartorato,Alessandra Murgia,F Moreno,I del Castillo +29 more
TL;DR: The finding of a large number of affected subjects with only one GJB2 mutant allele complicates the molecular diagnosis of DFNB1 deafness, which has become the standard of care for the diagnosis of patients with non-syndromic hearing impairment of unknown cause.
Journal ArticleDOI
Whole Exome Sequencing and Homozygosity Mapping Identify Mutation in the Cell Polarity Protein GPSM2 as the Cause of Nonsyndromic Hearing Loss DFNB82
Tom Walsh,Hashem Shahin,Tal Elkan-Miller,Ming K. Lee,Anne M. Thornton,Wendy Roeb,Amal Abu Rayyan,Suheir Loulus,Karen B. Avraham,Mary Claire King,Moien Kanaan +10 more
TL;DR: It is described how exome sequencing in conjunction with homozygosity mapping led to rapid identification of the causative allele for nonsyndromic hearing loss DFNB82 in a consanguineous Palestinian family.
Journal ArticleDOI
From flies' eyes to our ears: Mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30
Tom Walsh,Vanessa Walsh,Sarah Vreugde,Ronna Hertzano,Hashem Shahin,Smadar Haika,Ming K. Lee,Moien Kanaan,Mary Claire King,Karen B. Avraham +9 more
TL;DR: It is shown that normal hearing in humans requires myosin IIIA, the human homolog of NINAC, which is the involvement of homologous class III myosins in both Drosophila vision and human hearing.
Journal ArticleDOI
Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families.
Zippora Brownstein,Lilach M. Friedman,Hashem Shahin,Varda Oron-Karni,Nitzan Kol,Amal Abu Rayyan,Thomas Parzefall,Dorit Lev,Stavit A. Shalev,Stavit A. Shalev,Moshe Frydman,Bella Davidov,Mordechai Shohat,Mordechai Shohat,Michele Rahile,Sari Lieberman,Ephrat Levy-Lahad,Ephrat Levy-Lahad,Ming K. Lee,Noam Shomron,Mary Claire King,Tom Walsh,Moien Kanaan,Karen B. Avraham +23 more
TL;DR: Characterization of the proteins encoded by these genes will enable an understanding of the biological mechanisms involved in hearing loss and the integration of genomic analysis into early clinical diagnosis of hearing loss will enable prediction of related phenotypes and enhance rehabilitation.
Journal ArticleDOI
The prevalence and expression of inherited connexin 26 mutations associated with nonsyndromic hearing loss in the Israeli population.
Tama Sobe,Sarah Vreugde,Hashem Shahin,Mira Berlin,Noa Davis,Moien Kanaan,Yuval Yaron,Avi Orr-Urtreger,Moshe Frydman,Mordechai Shohat,Karen B. Avraham +10 more
TL;DR: The results suggest that, in Israel, clinicians should first screen for the common 167delT and 35delG mutations by simple and inexpensive restriction enzyme analysis, although if these are not found, sequencing should be done to rule out additional mutations due to the ethnic diversity in this region.