N
Nitzan Kol
Researcher at Sheba Medical Center
Publications - 33
Citations - 2732
Nitzan Kol is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Exome sequencing & Medicine. The author has an hindex of 11, co-authored 26 publications receiving 1989 citations. Previous affiliations of Nitzan Kol include Tel Aviv University.
Papers
More filters
Journal ArticleDOI
m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
Shay Geula,Sharon Moshitch-Moshkovitz,Dan Dominissini,Abed AlFatah Mansour,Nitzan Kol,Mali Salmon-Divon,Vera Hershkovitz,Eyal Peer,Nofar Mor,Yair S. Manor,Moshe Shay Ben-Haim,Eran Eyal,Sharon Yunger,Yishay Pinto,Diego Jaitin,Sergey Viukov,Yoach Rais,Vladislav Krupalnik,Elad Chomsky,Mirie Zerbib,Itay Maza,Yoav Rechavi,Rada Massarwa,Suhair Hanna,Suhair Hanna,Ido Amit,Erez Y. Levanon,Ninette Amariglio,Ninette Amariglio,Noam Stern-Ginossar,Noa Novershtern,Gideon Rechavi,Jacob H. Hanna +32 more
TL;DR: It is shown that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition from the pluripotent to the differentiated state.
Journal ArticleDOI
The dynamic N 1 -methyladenosine methylome in eukaryotic messenger RNA
Dan Dominissini,Dan Dominissini,Sigrid Nachtergaele,Sigrid Nachtergaele,Sharon Moshitch-Moshkovitz,Eyal Peer,Eyal Peer,Nitzan Kol,Moshe Shay Ben-Haim,Moshe Shay Ben-Haim,Qing Dai,Qing Dai,Ayelet Di Segni,Mali Salmon-Divon,Wesley C. Clark,Guanqun Zheng,Tao Pan,Oz Solomon,Oz Solomon,Eran Eyal,Vera Hershkovitz,Dali Han,Dali Han,Louis C. Dore,Louis C. Dore,Ninette Amariglio,Ninette Amariglio,Gideon Rechavi,Gideon Rechavi,Chuan He,Chuan He +30 more
TL;DR: It is shown that m1A is enriched around the start codon upstream of the first splice site: it preferentially decorates more structured regions around canonical and alternative translation initiation sites, is dynamic in response to physiological conditions, and correlates positively with protein production.
Journal ArticleDOI
Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families.
Zippora Brownstein,Lilach M. Friedman,Hashem Shahin,Varda Oron-Karni,Nitzan Kol,Amal Abu Rayyan,Thomas Parzefall,Dorit Lev,Stavit A. Shalev,Stavit A. Shalev,Moshe Frydman,Bella Davidov,Mordechai Shohat,Mordechai Shohat,Michele Rahile,Sari Lieberman,Ephrat Levy-Lahad,Ephrat Levy-Lahad,Ming K. Lee,Noam Shomron,Mary Claire King,Tom Walsh,Moien Kanaan,Karen B. Avraham +23 more
TL;DR: Characterization of the proteins encoded by these genes will enable an understanding of the biological mechanisms involved in hearing loss and the integration of genomic analysis into early clinical diagnosis of hearing loss will enable prediction of related phenotypes and enhance rehabilitation.
Journal ArticleDOI
Nm-seq maps 2′- O -methylation sites in human mRNA with base precision
Qing Dai,Sharon Moshitch-Moshkovitz,Dali Han,Dali Han,Nitzan Kol,Ninette Amariglio,Ninette Amariglio,Gideon Rechavi,Gideon Rechavi,Dan Dominissini,Dan Dominissini,Chuan He +11 more
TL;DR: Nm-seq uncovered thousands of Nm sites in human mRNA with features suggesting functional roles, and leveraged the differential reactivity of 2′-O-methylated and2′-hydroxylated nucleosides to periodate oxidation to develop Nm- sequencing, a sensitive method for transcriptome-wide mapping of Nn with base precision.
Journal ArticleDOI
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.
Amos J. Simon,Atar Lev,Yong Zhang,Batia Weiss,Anna Rylova,Eran Eyal,Nitzan Kol,Ortal Barel,Keren Cesarkas,Michalle Soudack,Noa Greenberg-Kushnir,Michele Rhodes,David L. Wiest,Ginette Schiby,Iris Barshack,Shulamit Katz,Elon Pras,Hana Poran,Haike Reznik-Wolf,Elena Ribakovsky,Carlos Simon,Wadi Hazou,Yechezkel Sidi,Avishay Lahad,Hagar Katzir,Shira Sagie,Haifa A. Aqeilan,Galina Glousker,Ninette Amariglio,Yehuda Tzfati,Sara Selig,Gideon Rechavi,Raz Somech +32 more
TL;DR: Two new mutations in STN1 that causes Coats plus syndrome and telomere abnormalities in human, recapitulated in a zebra fish model are identified.