M
Monika Vig
Researcher at Washington University in St. Louis
Publications - 19
Citations - 3985
Monika Vig is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: T cell & ORAI1. The author has an hindex of 14, co-authored 19 publications receiving 3805 citations. Previous affiliations of Monika Vig include Tata Institute of Fundamental Research & Massachusetts Institute of Technology.
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Journal ArticleDOI
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.
Monika Vig,Christine Peinelt,Andreas Beck,Dana Lynn T. Koomoa,D Rabah,M Koblan-Huberson,S Kraft,Helen Turner,Andrea Fleig,Reinhold Penner,J-P Kinet +10 more
TL;DR: The human ortholog of CRACM1, a plasma membrane–resident protein encoded by gene FLJ14466, was characterized and overexpression of CRacM1 did not affect CRAC currents, but RNAi-mediated knockdown disrupted its activation.
Journal ArticleDOI
Amplification of CRAC current by STIM1 and CRACM1 (Orai1).
Christine Peinelt,Monika Vig,Dana Lynn T. Koomoa,Andreas Beck,Monica J. S. Nadler,Murielle Koblan-Huberson,Annette Lis,Andrea Fleig,Reinhold Penner,Jean-Pierre Kinet +9 more
TL;DR: Overexpression of both proteins greatly potentiates ICRAC, suggesting that STIM1 and CRACM1 mutually limit store-operated currents and that CRacM1 may be the long-sought CRAC channel.
Journal ArticleDOI
CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel
Monika Vig,Andreas Beck,James M. Billingsley,Annette Lis,Suhel Parvez,Christine Peinelt,Dana Lynn T. Koomoa,Jonathan Soboloff,Donald L. Gill,Andrea Fleig,Jean-Pierre Kinet,Reinhold Penner +11 more
TL;DR: It is shown here that CRACM1 forms multimeric assemblies that bind STIM1 and that acidic residues in the transmembrane and extracellular domains of CRacM1 contribute to the ionic selectivity of the CRAC-channel pore.
Journal ArticleDOI
Calcium signaling in immune cells
Monika Vig,Jean-Pierre Kinet +1 more
TL;DR: This review highlights advances in the understanding of Ca2+ signaling in lymphocytes with special emphasis on SOC entry and discusses outstanding questions and probable future directions of the field.
Journal ArticleDOI
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.
Monika Vig,Wayne I. DeHaven,Gary S. Bird,James M. Billingsley,Huiyun Wang,Patricia E Rao,Amy Hutchings,Marie-Hélène Jouvin,James W. Putney,Jean-Pierre Kinet +9 more
TL;DR: CRACM1 is crucial in mouse mast cell effector function, but mouse T cell calcium release–activated calcium channels are functional in the absence of CRACM2, and CRACm2 expression to be much higher in mouse T cells.