J
Jonathan Soboloff
Researcher at Temple University
Publications - 90
Citations - 7441
Jonathan Soboloff is an academic researcher from Temple University. The author has contributed to research in topics: Endoplasmic reticulum & STIM1. The author has an hindex of 36, co-authored 81 publications receiving 6855 citations. Previous affiliations of Jonathan Soboloff include University Health Network & University of Ottawa.
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Journal ArticleDOI
STIM proteins: dynamic calcium signal transducers
TL;DR: Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.
Journal ArticleDOI
CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel
Monika Vig,Andreas Beck,James M. Billingsley,Annette Lis,Suhel Parvez,Christine Peinelt,Dana Lynn T. Koomoa,Jonathan Soboloff,Donald L. Gill,Andrea Fleig,Jean-Pierre Kinet,Reinhold Penner +11 more
TL;DR: It is shown here that CRACM1 forms multimeric assemblies that bind STIM1 and that acidic residues in the transmembrane and extracellular domains of CRacM1 contribute to the ionic selectivity of the CRAC-channel pore.
Journal ArticleDOI
Orai1 and STIM reconstitute store-operated calcium channel function.
Jonathan Soboloff,Maria A. Spassova,Xiang D. Tang,Thamara Hewavitharana,Wen Xu,Donald L. Gill +5 more
TL;DR: The results revealing a powerful gain in SOC function dependent on the presence of both Orai1 and STIM1 strongly suggest that ORAi1 contributes the PM channel component responsible for Ca2+ entry.
Journal ArticleDOI
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
TL;DR: The effects of the tarantula peptide on both stretch- and diacylglycerol-mediated TRPC6 activation indicate that the mechanical and chemical lipid sensing by the channel has a common molecular mechanism that may involve lateral-lipid tension.
Journal ArticleDOI
Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx EVIDENCE FOR SIMILARITIES IN STORE-OPERATED AND CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL COMPONENTS
Hwei Ling Ong,Kwong Tai Cheng,Xibao Liu,Bidhan C. Bandyopadhyay,Biman C. Paria,Jonathan Soboloff,Biswaranjan Pani,Yousang Gwack,Sonal Srikanth,Brij B. Singh,Donald L. Gill,Indu S. Ambudkar +11 more
TL;DR: In this article, the authors show that Orai1 and STIM1 are also required for TRPC1-SOC channels, and that dynamic assembly of TRPC 1-STIM 1-Orai 1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion.