M
Monique F. Murray-Thompson
Researcher at GlaxoSmithKline
Publications - 2
Citations - 348
Monique F. Murray-Thompson is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: HDAC9 & Histone deacetylase 5. The author has an hindex of 2, co-authored 2 publications receiving 288 citations.
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Journal ArticleDOI
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Mercedes Lobera,Kevin P. Madauss,Denise T Pohlhaus,Quentin G. Wright,Mark Trocha,Darby Schmidt,Erkan Baloglu,Ryan P. Trump,Martha S. Head,Glenn A. Hofmann,Monique F. Murray-Thompson,Benjamin Schwartz,Subhas J. Chakravorty,Zining Wu,Palwinder K. Mander,Laurens Kruidenier,Robert A. Reid,William Burkhart,Brandon J. Turunen,James X Rong,James X Rong,Craig D. Wagner,Mary B. Moyer,Carrow I. Wells,Xuan Hong,John T. Moore,Jon D. Williams,Dulce Soler,Shomir Ghosh,Michael A. Nolan +29 more
TL;DR: The discovery of inhibitors that fill this void with an unprecedented metal-binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates is reported.
Journal ArticleDOI
Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).
Yun Ding,Heather O’Keefe,Jennifer L. DeLorey,David I. Israel,Jeffrey A. Messer,Cynthia H. Chiu,Steven R. Skinner,Rosalie Matico,Monique F. Murray-Thompson,Fan Li,Matthew A. Clark,John W. Cuozzo,Christopher C. Arico-Muendel,Barry A. Morgan +13 more
TL;DR: DNA-encoded Library Technology (ELT) is used to identify novel ADAMTS-4 inhibitors from a DNA-encoding triazine library by affinity selection, leading to the identification of potent and highly selective inhibitors.