M
Mercedes Lobera
Researcher at GlaxoSmithKline
Publications - 45
Citations - 2274
Mercedes Lobera is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: T cell & RAR-related orphan receptor gamma. The author has an hindex of 15, co-authored 45 publications receiving 1858 citations. Previous affiliations of Mercedes Lobera include Wellesley College & Brandeis University.
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Journal ArticleDOI
Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells
Esen Sefik,Naama Geva-Zatorsky,Sungwhan F. Oh,Liza Konnikova,David Zemmour,Abigail Manson McGuire,Dalia Burzyn,Adriana Ortiz-Lopez,Mercedes Lobera,Jianfei Yang,Shomir Ghosh,Ashlee M. Earl,Scott B. Snapper,Ray Jupp,Dennis L. Kasper,Diane Mathis,Diane Mathis,Christophe Benoist,Christophe Benoist +18 more
TL;DR: It is reported that symbiotic members of the human gut microbiota induce a distinct Treg population in the mouse colon, which constrains immuno-inflammatory responses.
Journal ArticleDOI
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
Jennifer L. Guerriero,Alaba Sotayo,Holly Ponichtera,Jessica A. Castrillon,Alexandra Pourzia,Sara Schad,Shawn F. Johnson,Ruben D. Carrasco,Suzan Lazo,Roderick T. Bronson,Scott Davis,Mercedes Lobera,Michael A. Nolan,Anthony Letai +13 more
TL;DR: It is demonstrated that in vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes, and introduces class IIa HDAC inhibition as a means to harness the anti-tumour potential of macrophages to enhance cancer therapy.
Journal ArticleDOI
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Mercedes Lobera,Kevin P. Madauss,Denise T Pohlhaus,Quentin G. Wright,Mark Trocha,Darby Schmidt,Erkan Baloglu,Ryan P. Trump,Martha S. Head,Glenn A. Hofmann,Monique F. Murray-Thompson,Benjamin Schwartz,Subhas J. Chakravorty,Zining Wu,Palwinder K. Mander,Laurens Kruidenier,Robert A. Reid,William Burkhart,Brandon J. Turunen,James X Rong,James X Rong,Craig D. Wagner,Mary B. Moyer,Carrow I. Wells,Xuan Hong,John T. Moore,Jon D. Williams,Dulce Soler,Shomir Ghosh,Michael A. Nolan +29 more
TL;DR: The discovery of inhibitors that fill this void with an unprecedented metal-binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates is reported.
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Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Sheng Xiao,Nir Yosef,Jianfei Yang,Yonghui Wang,Ling Zhou,Chen Zhu,Chuan Wu,Erkan Baloglu,Darby Schmidt,Radha Ramesh,Mercedes Lobera,Mark S. Sundrud,Pei-Yun Tsai,Zhijun Xiang,Jinsong Wang,Yan Xu,Xichen Lin,Karsten Kretschmer,Peter B. Rahl,Richard A. Young,Zhong Zhong,David A. Hafler,Aviv Regev,Shomir Ghosh,Alexander Marson,Vijay K. Kuchroo +25 more
TL;DR: This paper identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease.
Journal ArticleDOI
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
Jill Skepner,Radha Ramesh,Mark Trocha,Darby Schmidt,Erkan Baloglu,Mercedes Lobera,Thaddeus J. Carlson,Jonathan Hill,Lisa A. Orband-Miller,Ashley A. Barnes,Mohamed Boudjelal,Mark S. Sundrud,Shomir Ghosh,Jianfei Yang +13 more
TL;DR: It is demonstrated that RORγt inverse agonists inhibit Tc17 cell differentiation, as well as IL-17 production by γδ T cells and CD8+ T c17 cells, and block imiquimod-induced cutaneous inflammation.