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Benjamin Schwartz
Researcher at GlaxoSmithKline
Publications - 24
Citations - 1808
Benjamin Schwartz is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Mutant & Histone H3. The author has an hindex of 16, co-authored 24 publications receiving 1487 citations.
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Journal ArticleDOI
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Lei Jiang,Alexander A. Shestov,Pamela Swain,Chendong Yang,Seth J. Parker,Qiong A. Wang,Lance S. Terada,Nicholas D. Adams,Michael T. McCabe,Beth Pietrak,Stan Schmidt,Christian M. Metallo,Brian P. Dranka,Benjamin Schwartz,Ralph J. DeBerardinis +14 more
TL;DR: The data indicate that adaptation to anchorage independence requires a fundamental change in citrate metabolism, initiated by IDH1-dependent reductive carboxylation and culminating in suppression of mitochondrial ROS.
Journal ArticleDOI
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Mercedes Lobera,Kevin P. Madauss,Denise T Pohlhaus,Quentin G. Wright,Mark Trocha,Darby Schmidt,Erkan Baloglu,Ryan P. Trump,Martha S. Head,Glenn A. Hofmann,Monique F. Murray-Thompson,Benjamin Schwartz,Subhas J. Chakravorty,Zining Wu,Palwinder K. Mander,Laurens Kruidenier,Robert A. Reid,William Burkhart,Brandon J. Turunen,James X Rong,James X Rong,Craig D. Wagner,Mary B. Moyer,Carrow I. Wells,Xuan Hong,John T. Moore,Jon D. Williams,Dulce Soler,Shomir Ghosh,Michael A. Nolan +29 more
TL;DR: The discovery of inhibitors that fill this void with an unprecedented metal-binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates is reported.
Journal ArticleDOI
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
Aidan G. Gilmartin,Faitg Thomas H,Mark Richter,Arthur Groy,Mark A. Seefeld,Michael G. Darcy,Peng Xin,Kelly Federowicz,Jingsong Yang,Shu-Yun Zhang,Elisabeth A. Minthorn,Jon-Paul Jaworski,Michael D. Schaber,Stan F. Martens,Dean E. McNulty,Robert H. Sinnamon,Hong Zhang,Robert B. Kirkpatrick,Neysa Nevins,Guanglei Cui,Beth Pietrak,Elsie Diaz,Amber D. Jones,Martin Brandt,Benjamin Schwartz,Dirk A. Heerding,Rakesh Kumar +26 more
TL;DR: GSK2830371 is the first orally active, allosteric inhibitor of Wip1 phosphatase, an oncogenic phosphat enzyme common to multiple cancers and results in expected pharmacodynamic effects and causes inhibition of lymphoma xenograft growth.
Journal ArticleDOI
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
Ujunwa C. Okoye-Okafor,Boris Bartholdy,Jessy Cartier,Enoch Gao,Beth Pietrak,Alan R. Rendina,Cynthia M. Rominger,Chad Quinn,Angela Smallwood,Kenneth Wiggall,Alexander Joseph Reif,Schmidt Stanley J,Hongwei Qi,Huizhen Zhao,Gerard Joberty,Maria Faelth-Savitski,Marcus Bantscheff,Gerard Drewes,Chaya Duraiswami,Pat Brady,Arthur Groy,Swathi Rao Narayanagari,Iléana Antony-Debré,Kelly Mitchell,Heng Rui Wang,Yun Ruei Kao,Maximilian Christopeit,Luis A. Carvajal,Laura Barreyro,Elisabeth Paietta,Hideki Makishima,Britta Will,Nestor O. Concha,Nicholas D. Adams,Benjamin Schwartz,Michael T. McCabe,Jaroslaw P. Maciejewski,Amit Verma,Ulrich Steidl +38 more
TL;DR: Crystallographic and biochemical results demonstrated that compounds of this chemical series bind to an allosteric site and lock the enzyme in a catalytically inactive conformation, thereby enabling inhibition of different clinically relevant IDH1 mutants.
Journal ArticleDOI
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
Han Dai,April Case,Thomas V. Riera,Thomas Considine,Jessica E. Lee,Yoshitomo Hamuro,Huizhen Zhao,Yong Jiang,Sharon Sweitzer,Beth Pietrak,Benjamin Schwartz,Charles A. Blum,Jeremy S. Disch,Richard Dana Caldwell,Bruce G. Szczepankiewicz,Christopher Oalmann,Pui Yee Ng,Brian H. White,Rebecca Casaubon,Radha Narayan,Karsten Koppetsch,Francis Bourbonais,Bo Wu,Junfeng Wang,Dongming Qian,Fan Jiang,Cheney Mao,Minghui Wang,Erding Hu,Joseph Wu,Robert B. Perni,George P. Vlasuk,James L. Ellis +32 more
TL;DR: The design and characterization of an engineered human SIRT1 construct containing the minimal structural elements required for lysine deacetylation and catalytic activation by small molecule sirtuin-activating compounds (STACs) are reported and the STAC-binding site within the N-terminal domain of hSIRT1 is revealed.