Moreno Ursino

TL;DR: In this paper, the effect of early invasive mechanical ventilation in patients with acute hypoxemic respiratory failure on day-60 mortality was investigated in a multicenter prospective French observational study.

TL;DR: Using PK information in the dose allocation process enriches the knowledge of the dose‐toxicity relationship, facilitating better dose recommendation for subsequent trials and improving the efficiency of dose‐finding trials.

TL;DR: The InSPiRe project has led to development of novel statistical methodology for clinical trials in small populations in four areas, including new decision-making methods for small population clinical trials using a Bayesian decision-theoretic framework.

TL;DR: The InSPiRe project as discussed by the authors developed decision-making methods for small population clinical trials using a Bayesian decision-theoretic framework to compare costs with potential benefits, developed approaches for targeted treatment trials, enabling simultaneous identification of subgroups and confirmation of treatment effect for these patients, worked on early phase clinical trial design and on extrapolation from adult to pediatric studies, developing methods to enable use of pharmacokinetics and pharmacodynamics data, and also developed improved robust meta-analysis methods for a small number of trials to support the planning, analysis and interpretation of a trial as

TL;DR: For patients with COVID-19 pneumonia, early CS treatment was not associated with patient survival, suggesting inflammation and age can significantly influence the effect of CS.