M
Motoko Shiozaki
Researcher at Osaka University
Publications - 16
Citations - 504
Motoko Shiozaki is an academic researcher from Osaka University. The author has contributed to research in topics: Transplantation & Induced pluripotent stem cell. The author has an hindex of 10, co-authored 15 publications receiving 430 citations. Previous affiliations of Motoko Shiozaki include Koshien University & Tokyo Metropolitan University.
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Journal ArticleDOI
Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice.
Motoko Shiozaki,Kentaro Yoshimura,Masahiro Shibata,Masato Koike,Nariaki Matsuura,Yasuo Uchiyama,Takahiro Gotow +6 more
TL;DR: The CNS neuronal alterations in klotho mutant mice were quite similar to those found in aged animals, including even premature death, so this mouse should be a more appropriate animal model for CNS aging than those previously reported.
Journal ArticleDOI
Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium
Junjun Li,Itsunari Minami,Motoko Shiozaki,Leqian Yu,Shin Yajima,Shigeru Miyagawa,Yuji Shiba,Nobuhiro Morone,Satsuki Fukushima,Momoko Yoshioka,Sisi Li,Jing Qiao,X. Li,Lin Wang,Hidetoshi Kotera,Norio Nakatsuji,Yoshiki Sawa,Yong Chen,Yong Chen,Li Liu +19 more
TL;DR: A handy framework for cardiac tissue engineering is established by cultivating hiPSC-CMs on low-thickness aligned nanofibers made of biodegradable poly(D,L-lactic-co-glycolic acid) polymer, resulting in upregulated cardiac biomarkers and enhanced cardiac functions.
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Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot–Marie–Tooth disease mutants
Takahiro Sasaki,Takahiro Gotow,Motoko Shiozaki,Fumika Sakaue,Taro Saito,Jean-Pierre Julien,Yasuo Uchiyama,Shin-ichi Hisanaga +7 more
TL;DR: Results indicate that the Pro22 CMT mutation induces abnormal filament aggregates by disrupting proper oligomer formation and the aggregates are mitigated by phosphorylation with PKA, which makes it a viable target for the development for therapeutics.
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Addition of Mesenchymal Stem Cells Enhances the Therapeutic Effects of Skeletal Myoblast Cell-Sheet Transplantation in a Rat Ischemic Cardiomyopathy Model
Yasuhiro Shudo,Shigeru Miyagawa,Hanayuki Ohkura,Satsuki Fukushima,Atsuhiro Saito,Motoko Shiozaki,Naomasa Kawaguchi,Nariaki Matsuura,Tatsuya Shimizu,Teruo Okano,Akifumi Matsuyama,Yoshiki Sawa +11 more
TL;DR: Adding MSCs to SMB cell sheets enhanced the sheets' angiogenesis-related paracrine mechanics and, consequently, functional recovery in a rat MI model, suggesting a possible strategy for clinical applications.
Journal ArticleDOI
Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart.
Satoshi Kainuma,Shigeru Miyagawa,Satsuki Fukushima,James T. Pearson,Yi Ching Chen,Atsuhiro Saito,Akima Harada,Motoko Shiozaki,Hiroko Iseoka,Tadashi Watabe,Hiroshi Watabe,Genki Horitsugi,Mana Ishibashi,Hayato Ikeda,Hirotsugu Tsuchimochi,Takashi Sonobe,Yutaka Fujii,Hisamichi Naito,Keiji Umetani,Tatsuya Shimizu,Teruo Okano,Eiji Kobayashi,Takashi Daimon,Takayoshi Ueno,Toru Kuratani,Koichi Toda,Nobuyuki Takakura,Jun Hatazawa,Mikiyasu Shirai,Yoshiki Sawa +29 more
TL;DR: In this article, the authors proposed that cell-sheet transplantation with an omentum-flap would effectively establish mature blood vessels and improve coronary microcirculation physiology, enhancing the therapeutic effects of cell sheet therapy.