R
Rosemarie H. DeKruyff
Researcher at Stanford University
Publications - 186
Citations - 21292
Rosemarie H. DeKruyff is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & Natural killer T cell. The author has an hindex of 72, co-authored 178 publications receiving 20251 citations. Previous affiliations of Rosemarie H. DeKruyff include Boston Children's Hospital & Harvard University.
Papers
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Journal ArticleDOI
Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen.
TL;DR: It is shown that IL-10 production by DCs is critical for the induction of tolerance, and that phenotypically mature pulmonary DCs mediate tolerance induced by respiratory exposure to antigen.
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Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
Omid Akbari,Gordon J. Freeman,Everett Meyer,Edward A. Greenfield,Tammy T. Chang,Arlene H. Sharpe,Gerald J. Berry,Rosemarie H. DeKruyff,Dale T. Umetsu +8 more
TL;DR: It is demonstrated that TR cells and the ICOS–ICOS-ligand signaling pathway are critically involved in respiratory tolerance and in downregulating pulmonary inflammation in asthma.
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Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
Ya-Jen Chang,Hye Young Kim,Lee A. Albacker,Nicole Baumgarth,Andrew Neil James Mckenzie,Dirk E. Smith,Rosemarie H. DeKruyff,Dale T. Umetsu +7 more
TL;DR: It is shown in a mouse model that influenza infection acutely induced airway hyper-reactivity (AHR), a cardinal feature of asthma, independently of T helper type 2 (TH2) cells and adaptive immunity.
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Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
Omid Akbari,Philippe Stock,Everett Meyer,Mitchell Kronenberg,Stephane Sidobre,Toshinori Nakayama,Masaru Taniguchi,Michael J. Grusby,Rosemarie H. DeKruyff,Dale T. Umetsu +9 more
TL;DR: Pulmonary Vα14i NKT cells crucially regulate the development of asthma and Th2-biased respiratory immunity against nominal exogenous antigens.
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Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation
TL;DR: It is indicated that antigen-specific Th1 cells may not protect or prevent Th2-mediated allergic disease, but rather may cause acute lung pathology.