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Mounsif Haloui

Researcher at Université de Montréal

Publications -  12
Citations -  240

Mounsif Haloui is an academic researcher from Université de Montréal. The author has contributed to research in topics: Diabetes mellitus & Ouabain. The author has an hindex of 7, co-authored 12 publications receiving 180 citations.

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Ubiquitous [Na+]i/[K+]i-Sensitive Transcriptome in Mammalian Cells: Evidence for Ca2+i-Independent Excitation-Transcription Coupling

TL;DR: In this article, the authors identified ubiquitous and tissue-specific [Na+]i/K+i-sensitive transcriptomes by comparative analysis of differentially expressed genes in vascular smooth muscle cells from rat aorta, the human adenocarcinoma cell line HeLa, and human umbilical vein endothelial cells (HUVEC).
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Transcriptomic changes triggered by hypoxia: evidence for HIF-1α-independent, [Na+]i/[K+]i-mediated, excitation-transcription coupling.

TL;DR: It is demonstrated, for the first time, that Na+ i/K+ i-mediated, Hif-1α- -independent excitation-transcription coupling contributes to transcriptomic changes evoked in RASMC by hypoxia and glucose deprivation.
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[Na]i -induced c-Fos expression is not mediated by activation of the 5' -promoter containing known transcriptional elements.

TL;DR: The results reveal that Na+i‐induced c‐Fos expression is not mediated by the 5′‐UTR containing transcriptional elements activated by growth factors and other ‘classic stimuli’.