M
Moussa B.H. Youdim
Researcher at National Institutes of Health
Publications - 21
Citations - 358
Moussa B.H. Youdim is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Monoamine oxidase & Serotonin. The author has an hindex of 9, co-authored 21 publications receiving 354 citations. Previous affiliations of Moussa B.H. Youdim include Technion – Israel Institute of Technology.
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Journal ArticleDOI
Does brain 5-HIAA indicate serotonin release or monoamine oxidase activity?
TL;DR: The question of whether serotonin is deaminated by MAO before it can be released or after release has occurred was investigated by studying the 5-HT behavioral syndrome in acutely reserpinized rats, leading to the conclusion that serotonin does not have to be released before it is metabolized to 5-hydroxyindoleacetic acid.
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Contrasting monoamine oxidase activity and tyramine induced catecholamine release in PC12 and chromaffin cells.
TL;DR: In similar fashion to peripheral adrenergic neurons, PC12 cells share the capacity to express a tyramine releasable pool of catecholamines, a property entirely lacking in mature cultured chromaffin cells, even though the latter cells are capable of taking up tyramines by a cocaine sensitive process.
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Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells.
Ian A. Paul,Anthony S. Basile,Eduardo Rojas,Moussa B.H. Youdim,B. R. De Costa,Phil Skolnick,Harvey B. Pollard,Gemma A. J. Kuijpers +7 more
TL;DR: It is reported that σ receptor ligands noncompetitively inhibit nicotine‐stimulated catecholamine release from bovine adrenal chromaffin cells in a concentration‐dependent and reversible manner and the actions of agonists at the nicotinic acetylcholine receptor in bovines chromaff in cells are modulated by σ1 receptor selective ligands.
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Monoaminergic involvement in the pharmacological actions of buspirone.
TL;DR: Parenterally administered buspirone blocked apomorphine‐induced sterotypy, inhibited the 5‐HT syndrome elicited by 5‐methoxy‐N,N‐dimethyltryptamine, and delayed the onset of p‐chloroamphetamine induced behaviours.
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Isolated chromaffin cells from adrenal medulla contain primarily monoamine oxidase B.
TL;DR: Cultured chromaffin cells from bovine adrenal medulla were found to contain primarily the B form of monoamine oxidase, which is consistent with physiological needs that require the cell to synthesize and store large amounts of catecholamines.