Moustafa R. K. Ali

TL;DR: The 28 × 8 nm AuNR was found to be the most effective photothermal contrast agent for PPTT of human oral squamous cell carcinoma as mentioned in this paper, which is the smallest size of AuNR.

TL;DR: In this paper, the most recent achievements and challenges associated with using AuNPs to improve resolution and sensitivity in biological imaging in vitro and in vivo were discussed, including direct visualization of AuNs inside the biosystems using i) dark field (DF) microscopy, ii) differential interference contrast (DIC), and iii) other techniques, such as interferometric scattering microscopy and photothermal imaging.

TL;DR: A one-pot seedless synthetic technique has been developed to prepare relatively small monodisperse gold nanorods with average dimensions, and the pH was found to play a crucial role in the monodispersity of the nanorod when the NaBH(4) concentration of the growth solution was adjusted to control the reduction rate of the gold ions.

TL;DR: The optimized properties of AuNRs and the conditions of PPTT to achieve maximal induction of tumor apoptosis and quantitative proteomics analysis in mouse tumor tissues suggest that the Au NRs-PPTT has potential as an approach to cancer therapy, and a long-term toxicity study shows that the platform is effective and safe for cancer therapy in mouse models.

TL;DR: The most recent scientific progress is summarized, including the efficacy, molecular mechanism, toxicity, and pharmacokinetics of PPTT in vitro with cancer cells and in vivo through mouse/rat model testing, animal clinical cases, and human clinical trials.