Haopeng Xiao

TL;DR: The optimized properties of AuNRs and the conditions of PPTT to achieve maximal induction of tumor apoptosis and quantitative proteomics analysis in mouse tumor tissues suggest that the Au NRs-PPTT has potential as an approach to cancer therapy, and a long-term toxicity study shows that the platform is effective and safe for cancer therapy in mouse models.

TL;DR: Oximouse is developed, a comprehensive and quantitative mapping of the mouse cysteine redox proteome in vivo that comprehensively identifies redox-modified disease networks that remodel in aged mice, establishing a systemic molecular basis for the long-standing proposed links between redox dysregulation and tissue aging.

TL;DR: The ability of targeting AuNRs to cancer cell surface integrins and the introduction of NIR light to generate a mild plasmonic photothermal effect caused broad regulation on cytoskeletal proteins, thus impairing cancer cell migration and providing a potential medical application for controlling cancer metastasis.

TL;DR: This study shows that the integration of the SERS with MS-based metabolomics and proteomics can assist the assignment of signals in SERS spectra and further characterize the related molecular mechanisms of the cellular processes involved in PPTT.

TL;DR: A bioenergetic sensor in muscle is defined that utilizes intracellular pH and succinate to coordinate tissue adaptation to exercise.