M
Muhammad Taha
Researcher at University of Dammam
Publications - 322
Citations - 7515
Muhammad Taha is an academic researcher from University of Dammam. The author has contributed to research in topics: Chemistry & Acarbose. The author has an hindex of 38, co-authored 268 publications receiving 5019 citations. Previous affiliations of Muhammad Taha include Quaid-i-Azam University & University of Karachi.
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Journal ArticleDOI
Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
Muhammad Taha,Nor Hadiani Ismail,Salima Lalani,Muhammad Qaiser Fatmi,Atia-tul-Wahab,Salman Siddiqui,Khalid Mohammed Khan,Syahrul Imran,Muhammad Iqbal Choudhary +8 more
TL;DR: The predicted physico-chemical properties indicated the drug appropriateness for most of these compounds, as they obey Lipinski's rule of five (RO5), and a new class of α-glucosidase inhibitors was identified.
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Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies.
Fazal Rahim,Fazal Malik,Hayat Ullah,Abdul Wadood,Fahad Khan,Muhammad Javid,Muhammad Taha,Wajid Rehman,Ashfaq Ur Rehman,Khalid Mohammed Khan +9 more
TL;DR: Isatin base Schiff bases (1-20) were synthesized, characterized by (1)H NMR and EI/MS and evaluated for α-glucosidase inhibitory potential and the binding interactions of these active analogs were confirmed through molecular docking.
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Synthesis of bis-Schiff bases of isatins and their antiglycation activity.
Khalid Mohammed Khan,Momin Khan,Muhammad Ali,Muhammad Taha,Saima Rasheed,Shahnaz Perveen,M. Iqbal Choudhary +6 more
TL;DR: This study has identified a series of potential molecules as antiglycation agents and all the compounds were characterized by spectroscopic techniques.
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Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton.
Khalid Mohammed Khan,Fazal Rahim,Abdul Wadood,Naveen Kosar,Muhammad Taha,Salima Lalani,Aisha Khan,Muhammad Imran Fakhri,Muhammad Junaid,Wajid Rehman,Momin Khan,Shahnaz Perveen,Muhammad Sajid,M. Iqbal Choudhary +13 more
TL;DR: This study has identified a new class of potent α-glucosidase inhibitors, based on the binding interactions of biscoumarin derivatives with the enzyme, that are applicable to the treatment of diabetes.
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Triazinoindole analogs as potent inhibitors of α-glucosidase: synthesis, biological evaluation and molecular docking studies.
Fazal Rahim,Khadim Ullah,Hayat Ullah,Abdul Wadood,Muhammad Taha,Ashfaq Ur Rehman,Imad Uddin,Muhammad Ashraf,Ayesha Shaukat,Wajid Rehman,Shafqat Hussain,Khalid Mohammed Khan +11 more
TL;DR: A new series of triazinoindole analogs 1-11 were synthesized, characterized by EI-MS and (1)H NMR, evaluated for α-glucosidase inhibitory potential, and showed good enzyme inhibition.