Journal ArticleDOI
Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies.
Fazal Rahim,Fazal Malik,Hayat Ullah,Abdul Wadood,Fahad Khan,Muhammad Javid,Muhammad Taha,Wajid Rehman,Ashfaq Ur Rehman,Khalid Mohammed Khan +9 more
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TLDR
Isatin base Schiff bases (1-20) were synthesized, characterized by (1)H NMR and EI/MS and evaluated for α-glucosidase inhibitory potential and the binding interactions of these active analogs were confirmed through molecular docking.About:
This article is published in Bioorganic Chemistry.The article was published on 2015-06-01. It has received 149 citations till now. The article focuses on the topics: Isatin & Acarbose.read more
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Isatin and its derivatives: a survey of recent syntheses, reactions, and applications.
Varun,Sonam,Rita Kakkar +2 more
TL;DR: In this review, several novel methods for the synthesis of N-, C2-, and C3-substituted and spiro derivatives of isatin are reported, which show important chemical reactions such as oxidation, ring expansion, Friedel-Crafts reaction and aldol condensation.
Journal ArticleDOI
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview.
Manoj Dhameja,Preeti Gupta +1 more
TL;DR: This review deals with recently discovered heterocyclic molecules that have been evaluated to exhibit inhibition of α-glucosidase enzyme in the treatment of type 2 diabetes mellitus.
Journal ArticleDOI
Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors.
TL;DR: The studies shown that these triazine-triazole derivatives are a new class of α-glucosidase inhibitors.
Journal ArticleDOI
Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease.
Fazal Rahim,Muhammad Tariq Javed,Hayat Ullah,Abdul Wadood,Muhammad Taha,Muhammad Ashraf,Qurat-ul-Ain,Muhammad Anas Khan,Fahad Khan,Salma Mirza,Khalid Mohammed Khan +10 more
TL;DR: A series of thirty thiazole analogs were prepared, characterized by (1)H NMR, (13)C NMR and EI-MS and evaluated for Acetylcholinesterase and butyrylcholiersterase inhibitory potential, and exhibited well to moderate enzyme inhibition.
Journal ArticleDOI
Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study.
Mina Saeedi,Maryam Mohammadi-Khanaposhtani,Parvaneh Pourrabia,Nima Razzaghi,Reza Ghadimi,Somaye Imanparast,Mohammad Ali Faramarzi,Fatemeh Bandarian,Ensieh Nasli Esfahani,Maliheh Safavi,Hossein Rastegar,Bagher Larijani,Mohammad Mahdavi,Tahmineh Akbarzadeh +13 more
TL;DR: A novel series of quinazolinone-1,2,3-triazole hybrids 10a-p were designed, synthesized, and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti-diabetic agents and lack of cytotoxicity of compounds 10g and 10p was confirmed via MTT assay.
References
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Journal ArticleDOI
Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide
TL;DR: Isatin, its 5-chloro and 5-bromo derivatives have been reacted with N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and three secondary amines.
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Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus.
TL;DR: In long term, well designed trials miglitol reduces fasting and postprandial plasma glucose levels, thus improving glycaemic control, which is reflected in a reduced HbA1c level in patients with type 2 diabetes mellitus.
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Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
Nicole Zitzmann,Anand Mehta,Sandra Carrouee,Terry D. Butters,Frances M. Platt,John W. McCauley,Baruch S. Blumberg,Raymond A. Dwek,Timothy M. Block +8 more
TL;DR: It is shown that in MDBK cells alpha-glucosidase inhibitors prevented the formation and secretion of infectious bovine viral diarrhea virus and data is presented showing that NN-DNJ, compared with NB- DNJ, exhibits a prolonged retention in liver in vivo.
Journal ArticleDOI
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Bruce D. Walker,Mark Kowalski,Wei Chun Goh,Karen Kozarsky,Monty Krieger,Craig A. Rosen,Larry R. Rohrschneider,William A. Haseltine,Joseph Sodroski +8 more
TL;DR: The antiviral effects of castanospermine may be due to modifications of the envelope glycoprotein that affect the ability of the virus to enter cells after attachment to the CD4 cell receptor.
Journal ArticleDOI
Synthesis, biological activity, and molecular modeling studies of 1H-1,2,3-triazole derivatives of carbohydrates as alpha-glucosidases inhibitors.
Sabrina Baptista Ferreira,Ana C. R. Sodero,Mariana F. C. Cardoso,Emerson Silva Lima,Carlos R. Kaiser,Floriano P. Silva,Vitor F. Ferreira +6 more
TL;DR: The synthesis of a series of 4-substituted 1,2,3-triazoles conjugated with sugars that could represent new chemical scaffolds for developing novel drugs against type II diabetes mellitus were demonstrated by the reduction of postprandial blood glucose levels in normal rats.