M
Munenori Takaoka
Researcher at University of Pennsylvania
Publications - 10
Citations - 2217
Munenori Takaoka is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Growth factor & Cell growth. The author has an hindex of 8, co-authored 10 publications receiving 2080 citations. Previous affiliations of Munenori Takaoka include Okayama University.
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Journal ArticleDOI
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Jirina Bartkova,Nousin Rezaei,Michalis Liontos,Panagiotis Karakaidos,Dimitris Kletsas,Natalia Issaeva,Leandros-Vassilios F. Vassiliou,Evangelos Kolettas,Katerina Niforou,Vassilis Zoumpourlis,Munenori Takaoka,Hiroshi Nakagawa,Frederic Tort,Kasper Fugger,Fredrik Johansson,Maxwell Sehested,Claus L. Andersen,Lars Dyrskjøt,Torben F. Ørntoft,Jiri Lukas,Christos Kittas,Thomas Helleday,Thomas Helleday,Thanos D. Halazonetis,Thanos D. Halazonetis,Jiri Bartek,Vassilis G. Gorgoulis +26 more
TL;DR: It is shown that oncogene-induced senescence is associated with signs of DNA replication stress, including prematurely terminated DNA replication forks and DNA double-strand breaks, and, together with apoptosis, provides a barrier to malignant progression.
Journal ArticleDOI
Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis
James J. Lee,Mitsuteru Natsuizaka,Shinya Ohashi,Gabrielle S. Wong,Munenori Takaoka,Munenori Takaoka,Carmen Z. Michaylira,Daniela Budo,John W. Tobias,Michiyuki Kanai,Yasuhiro Shirakawa,Yoshio Naomoto,Andres J. Klein-Szanto,Volker H. Haase,Hiroshi Nakagawa +14 more
TL;DR: PTGES is a novel HIF-1alpha target gene, involved in prostaglandin E biosynthesis in the esophageal tumor hypoxic microenvironment, and this has implications in diverse tumors types, especially of squamous origin.
Journal ArticleDOI
Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3.
Munenori Takaoka,Hideki Harada,Claudia D. Andl,Kenji Oyama,Yoshio Naomoto,Kelly L. Dempsey,Andres J. Klein-Szanto,Wafik S. El-Deiry,Adda Grimberg,Hiroshi Nakagawa +9 more
TL;DR: Insulin-like growth factor-binding protein (IGFBP)-3 is identified as the most up-regulated gene and it is identified for the first time that IGFBP-3 is an aberrantly regulated gene through the EGFR signaling pathway and it may modulate EGFR effects during carcinogenesis.
Journal ArticleDOI
AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture
Kenji Oyama,Takaomi Okawa,Hiroshi Nakagawa,Munenori Takaoka,Claudia D. Andl,Sabrina Kim,Andres J. Klein-Szanto,J A Diehl,Meenhard Herlyn,Wafik S. El-Deiry,Anil K. Rustgi +10 more
TL;DR: It is demonstrated that the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway, and not the MEK/MAPK (mitogen-activated protein kinase) pathway, is preferentially activated in EGFR-mediated esophageal epithelial hyperplasia, a premalignant lesion.
Journal ArticleDOI
Ha-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction.
Munenori Takaoka,Hideki Harada,Therese B. Deramaudt,Kenji Oyama,Claudia D. Andl,Cameron N. Johnstone,Ben Rhoades,Gregory H. Enders,Oliver G. Opitz,Hiroshi Nakagawa +9 more
TL;DR: In human esophageal keratinocytes, it was found that Ha-RasG12V induced senescence regardless of p53 status and telomerase activation, suggesting that Ras-mediated senescences may involve distinct mechanisms between human and mouse cells.