Vassilis Zoumpourlis

TL;DR: It is shown that oncogene-induced senescence is associated with signs of DNA replication stress, including prematurely terminated DNA replication forks and DNA double-strand breaks, and, together with apoptosis, provides a barrier to malignant progression.

TL;DR: In this paper, the authors show that senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with opoptosis, provides a barrier to malignant progression.

TL;DR: This work validated the histochemical Sudan-Black-B (SBB) specific stain of lipofuscin, an aggregate of oxidized proteins, lipids and metals, known to accumulate in aged tissues, as an additional reliable approach to detect senescent cells independently of sample preparation, strongly supporting the candidacy of lip ofuscin for a biomarker of cellular senescence.

TL;DR: Stable expression of hCdc6 and hCdt1 in premalignant papilloma cells led to transformation of the cells that produced tumors upon injection into nude mice depicting the oncogenic potential of their deregulation.

TL;DR: An extensive allelotype study of 80 specimens of squamous cell carcinoma of the head and neck using 145 polymorphic microsatellite markers indicates that assessment of the accumulation of genetic damage, as provided by allelotypes, provides a useful molecular indicator of the tumour behaviour and clinical outcome.