M
Myles R. Minter
Researcher at University of Melbourne
Publications - 12
Citations - 1390
Myles R. Minter is an academic researcher from University of Melbourne. The author has contributed to research in topics: JAK-STAT signaling pathway & Interferon. The author has an hindex of 11, co-authored 12 publications receiving 960 citations. Previous affiliations of Myles R. Minter include University of Chicago.
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Journal ArticleDOI
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease
Myles R. Minter,Can Zhang,Vanessa Leone,Daina L. Ringus,Xiaoqiong Zhang,Paul Oyler-Castrillo,Mark W. Musch,Fan Liao,Joseph Ward,David M. Holtzman,Eugene B. Chang,Rudolph E. Tanzi,Sangram S. Sisodia +12 more
TL;DR: It is shown that prolonged shifts in gut microbial composition and diversity induced by long-term broad-spectrum combinatorial antibiotic treatment regime decreases Aβ plaque deposition and attenuated plaque-localised glial reactivity in these mice and significantly altered microglial morphology.
Journal ArticleDOI
The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
TL;DR: Evidence supporting the combined neuroinflammatory‐amyloid hypothesis for pathogenesis of AD is described, describing the key cell types, pathways and mediators involved.
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Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP SWE /PS1 ΔE9 murine model of Alzheimer’s disease
Myles R. Minter,Reinhard Hinterleitner,Marlies Meisel,Can Zhang,Vanessa Leone,Xiaoqiong Zhang,Paul Oyler-Castrillo,Xulun Zhang,Mark W. Musch,Xunuo Shen,Bana Jabri,Eugene B. Chang,Rudolph E. Tanzi,Sangram S. Sisodia +13 more
TL;DR: It is shown that early post-natal ABX treatment results in long-term alterations of gut microbial genera and reduction in brain Aβ deposition in aged APPSWE/PS1ΔE9 mice and it is confirmed that plaque-localised microglia and astrocytes are reduced in ABX-exposed mice.
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Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease
TL;DR: A role for type-1 interferons in the pro-inflammatory response and neuronal cell death in AD is supported and blocking type- 1 interferon-α receptor 1 maybe a therapeutic target to limit the disease progression is suggested.
Journal ArticleDOI
Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules
Aneesh T. Veetil,Kasturi Chakraborty,Kangni Xiao,Myles R. Minter,Sangram S. Sisodia,Yamuna Krishnan +5 more
TL;DR: This work combines a cell-targetable, icosahedral DNA-nanocapsule loaded with photoresponsive polymers with sequestration inside the DNA capsule to release dehydroepiandrosterone (DHEA), a neurosteroid that promotes neurogenesis and neuron survival, and determined the timescale of neuronal activation by DHEA.