N. Castex-Rizzi

TL;DR: Fragile skin is very frequent worldwide and its prevalence varies between 25% and 52% in Caucasian, African and Asian population and this article includes also clinical cases and differential diagnosis of fragile skin (reactive skin) in face in adult population.

TL;DR: Within their first days of life, newborns’ skin undergoes various adaptation processes needed to accommodate the transition from the wet uterine environment to the dry atmosphere.

TL;DR: A model of epidermis reconstructed from ORS cells (ORS‐derived model) is characterized and its reproducibility evaluated, in comparison with native human skin and two marketed reconstructed skin models.

TL;DR: Five in vitro models that mimic the pathomechanisms of atopic dermatitis are described – the AD keratinocyte model, the AD reconstructed human epidermismodel, the adaptive immunity model,The innate immunity model and the pruritus model – which are used to evaluate a new ingredient for emollients derived from a biological extract.

TL;DR: It is shown that Th17/Th22 cytokines, main inflammatory parameters, and psoriasis associated key biomarkers were inhibited by CEE in both 2D and 3D human in vitro models, suggesting skin homeostasis could be restored by these modulator effects.