N
Nai-Kong V. Cheung
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 410
Citations - 19855
Nai-Kong V. Cheung is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Antibody & Neuroblastoma. The author has an hindex of 75, co-authored 381 publications receiving 17744 citations. Previous affiliations of Nai-Kong V. Cheung include Kettering University & University Hospitals of Cleveland.
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Neuroblastoma: developmental biology, cancer genomics and immunotherapy
TL;DR: The key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma are discussed, as well as new translational tools for bringing these promising scientific advances into the clinic.
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Ganglioside GD2 specific monoclonal antibody 3F8: a phase I study in patients with neuroblastoma and malignant melanoma.
Nai-Kong V. Cheung,Hillard M. Lazarus,F. D. Miraldi,Carlos R. Abramowsky,S. Kallick,U. M. Saarinen,Thomas R. Spitzer,S. E. Strandjord,Peter F. Coccia,Nathan A. Berger +9 more
TL;DR: In a phase I study, 3F8 was administered intravenously to 17 patients with metastatic GD2 positive neuroblastoma or malignant melanoma at doses of 5, 20, 50, and 100 mg/m2, and mixed responses ranged from complete clinical remissions to mixed responses.
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Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma
Nai-Kong V. Cheung,Jinghui Zhang,Charles Lu,Matthew Parker,Armita Bahrami,Satish K. Tickoo,Adriana Heguy,Alberto S. Pappo,Sara M. Federico,James T. Dalton,Irene Y. Cheung,Li Ding,Robert S. Fulton,Jianmin Wang,Xiang Chen,Jared Becksfort,Jianrong Wu,Catherine A. Billups,David H. Ellison,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Michael A. Dyer +22 more
TL;DR: Somatic recurrent mutations in tumors from patients with neuroblastoma correlated with the age at diagnosis and telomere length, and ATRX mutations were associated with age atdiagnosis in children and young adults with stage 4 neuroblastomas.
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Radioimmunotherapy of human tumours
TL;DR: The cumulative advances in cancer biology, antibody engineering and radiochemistry in the past decade have markedly enhanced the ability of RIT to produce durable remissions of multiple cancer types.
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Association of CYP3A4 genotype with treatment-related leukemia
Carolyn A. Felix,Amy H. Walker,Beverly J. Lange,Terence M. Williams,Naomi J. Winick,Nai-Kong V. Cheung,Brian D. Lovett,Peter C. Nowell,Ian A. Blair,Timothy R. Rebbeck +9 more
TL;DR: The data suggest that individuals with CYP3A4-W genotype may be at increased risk for treatment-related leukemia and that epipodophyllotoxin metabolism by CYP 3A4 may contribute to the secondary cancer risk.