A
Armita Bahrami
Researcher at St. Jude Children's Research Hospital
Publications - 107
Citations - 5614
Armita Bahrami is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Sarcoma & Cancer. The author has an hindex of 31, co-authored 103 publications receiving 4485 citations. Previous affiliations of Armita Bahrami include Baylor College of Medicine & Mayo Clinic.
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Journal ArticleDOI
Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma
Xiang Chen,Armita Bahrami,Alberto S. Pappo,John Easton,James T. Dalton,Erin Hedlund,David H. Ellison,Sheila A. Shurtleff,Gang Wu,Lei Wei,Matthew Parker,Michael Rusch,Panduka Nagahawatte,Jianrong Wu,Shenghua Mao,Kristy Boggs,Heather L. Mulder,Donald Yergeau,Charles Lu,Li Ding,Michael N. Edmonson,Chunxu Qu,Jianmin Wang,Yongjin Li,Fariba Navid,Najat C. Daw,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang,Michael A. Dyer +30 more
TL;DR: The authors performed whole-genome sequencing of DNA from 20 osteosarcoma tumor samples and matched normal tissue in a discovery cohort, as well as 14 samples in a validation cohort.
Journal ArticleDOI
A novel retinoblastoma therapy from genomic and epigenetic analyses
Jinghui Zhang,Claudia A. Benavente,Justina McEvoy,Jacqueline Flores-Otero,Li Ding,Xiang Chen,Anatoly Ulyanov,Gang Wu,Matthew W. Wilson,Matthew W. Wilson,Jianmin Wang,Rachel C. Brennan,Michael Rusch,Amity L. Manning,Jing Ma,John Easton,Sheila A. Shurtleff,Charles G. Mullighan,Stanley Pounds,Suraj Mukatira,Pankaj Gupta,Geoff Neale,David Zhao,Charles Lu,Robert S. Fulton,Lucinda Fulton,Xin Hong,David J. Dooling,Kerri Ochoa,Clayton W. Naeve,Nicholas J. Dyson,Elaine R. Mardis,Armita Bahrami,David H. Ellison,Richard K. Wilson,James R. Downing,Michael A. Dyer,Michael A. Dyer +37 more
TL;DR: It is shown that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated, and that the proto-oncogene SYK is upregulated in retinOBlastoma and is required for tumour cell survival.
Journal ArticleDOI
Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations
Franck Tirode,Didier Surdez,Xiaotu Ma,Matthew Parker,Marie-Cécile Le Deley,Armita Bahrami,Zhaojie Zhang,Eve Lapouble,Sandrine Grossetête-Lalami,Michael Rusch,Stéphanie Reynaud,Thomas Rio-Frio,Erin Hedlund,Gang Wu,Xiang Chen,Gaëlle Pierron,Odile Oberlin,Sakina Zaidi,Gordon Lemmon,Pankaj Gupta,Bhavin Vadodaria,John Easton,Marta Gut,Li Ding,Elaine R. Mardis,Richard K. Wilson,Sheila A. Shurtleff,Valérie Laurence,Jean Michon,Perrine Marec-Berard,Ivo Gut,James R. Downing,Michael A. Dyer,Michael A. Dyer,Jinghui Zhang,Olivier Delattre +35 more
TL;DR: Tumors that harbor STAG2 and TP53 mutations have a particularly dismal prognosis with current treatments and require alternative therapies, and novel drugs that target epigenetic regulators may constitute viable therapeutic strategies in a subset of patients with mutations in chromatin modifiers.
Journal ArticleDOI
Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma
Nai-Kong V. Cheung,Jinghui Zhang,Charles Lu,Matthew Parker,Armita Bahrami,Satish K. Tickoo,Adriana Heguy,Alberto S. Pappo,Sara M. Federico,James T. Dalton,Irene Y. Cheung,Li Ding,Robert S. Fulton,Jianmin Wang,Xiang Chen,Jared Becksfort,Jianrong Wu,Catherine A. Billups,David H. Ellison,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Michael A. Dyer +22 more
TL;DR: Somatic recurrent mutations in tumors from patients with neuroblastoma correlated with the age at diagnosis and telomere length, and ATRX mutations were associated with age atdiagnosis in children and young adults with stage 4 neuroblastomas.
Journal ArticleDOI
Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma
Xiang Chen,Elizabeth Stewart,Anang A. Shelat,Chunxu Qu,Armita Bahrami,Mark E. Hatley,Gang Wu,Cori Bradley,Justina McEvoy,Alberto S. Pappo,Sheri L. Spunt,Marcus B. Valentine,Virginia Valentine,Fred Krafcik,Walter H. Lang,Monika Wierdl,Lyudmila Tsurkan,Viktor Tolleman,Sara M. Federico,Christopher L. Morton,Charles Lu,Li Ding,John Easton,Michael Rusch,Panduka Nagahawatte,Jianmin Wang,Matthew Parker,Lei Wei,Erin Hedlund,David Finkelstein,Michael N. Edmonson,Sheila A. Shurtleff,Kristy Boggs,Heather L. Mulder,Donald Yergeau,Steve Skapek,Douglas S. Hawkins,Nilsa C. Ramirez,Philip M. Potter,John A. Sandoval,Andrew M. Davidoff,Elaine R. Mardis,Richard K. Wilson,Jinghui Zhang,James R. Downing,Michael A. Dyer +45 more
TL;DR: High-throughput screening of primary cultures derived from orthotopic xenografts of tumors that were sequenced identified oxidative stress as a pathway of therapeutic relevance for ERMS.