M
Michael A. Dyer
Researcher at St. Jude Children's Research Hospital
Publications - 164
Citations - 13352
Michael A. Dyer is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Retinoblastoma & Retina. The author has an hindex of 54, co-authored 146 publications receiving 11438 citations. Previous affiliations of Michael A. Dyer include University of Tennessee & Howard Hughes Medical Institute.
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Journal ArticleDOI
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
Gang Wu,Alberto Broniscer,Troy A. McEachron,Charles Lu,Barbara S. Paugh,Jared Becksfort,Chunxu Qu,Li Ding,Robert Huether,Matthew Parker,Junyuan Zhang,Amar Gajjar,Michael A. Dyer,Charles G. Mullighan,Richard J. Gilbertson,Elaine R. Mardis,Richard K. Wilson,James R. Downing,David W. Ellison,Jinghui Zhang,Suzanne J. Baker +20 more
TL;DR: To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPG and 36 non-brainstem pediatric glioblastomas (non-BS-PGs) were performed.
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Neuroblastoma: developmental biology, cancer genomics and immunotherapy
TL;DR: The key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma are discussed, as well as new translational tools for bringing these promising scientific advances into the clinic.
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Inactivation of the p53 pathway in retinoblastoma
Nikia A. Laurie,Stacy L. Donovan,Chie Schin Shih,Jiakun Zhang,Nicholas Mills,Christine E. Fuller,Amina F A S Teunisse,Suzanne Lam,Yolande F. M. Ramos,Adithi Mohan,Dianna A. Johnson,Matthew W. Wilson,Carlos Rodriguez-Galindo,Micaela Quarto,Sarah Francoz,Susan M. Mendrysa,R. Kiplin Guy,Jean-Christophe Marine,Aart G. Jochemsen,Michael A. Dyer +19 more
TL;DR: It is shown that the tumour surveillance pathway mediated by Arf, MDM2, MDMX and p53 is activated after loss of RB1 during retinogenesis, providing evidence that the p53 pathway is inactivated in retinoblastoma and that this cancer does not originate from intrinsically death-resistant cells as previously thought.
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Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma
Xiang Chen,Armita Bahrami,Alberto S. Pappo,John Easton,James T. Dalton,Erin Hedlund,David H. Ellison,Sheila A. Shurtleff,Gang Wu,Lei Wei,Matthew Parker,Michael Rusch,Panduka Nagahawatte,Jianrong Wu,Shenghua Mao,Kristy Boggs,Heather L. Mulder,Donald Yergeau,Charles Lu,Li Ding,Michael N. Edmonson,Chunxu Qu,Jianmin Wang,Yongjin Li,Fariba Navid,Najat C. Daw,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang,Michael A. Dyer +30 more
TL;DR: The authors performed whole-genome sequencing of DNA from 20 osteosarcoma tumor samples and matched normal tissue in a discovery cohort, as well as 14 samples in a validation cohort.
Journal ArticleDOI
A novel retinoblastoma therapy from genomic and epigenetic analyses
Jinghui Zhang,Claudia A. Benavente,Justina McEvoy,Jacqueline Flores-Otero,Li Ding,Xiang Chen,Anatoly Ulyanov,Gang Wu,Matthew W. Wilson,Matthew W. Wilson,Jianmin Wang,Rachel C. Brennan,Michael Rusch,Amity L. Manning,Jing Ma,John Easton,Sheila A. Shurtleff,Charles G. Mullighan,Stanley Pounds,Suraj Mukatira,Pankaj Gupta,Geoff Neale,David Zhao,Charles Lu,Robert S. Fulton,Lucinda Fulton,Xin Hong,David J. Dooling,Kerri Ochoa,Clayton W. Naeve,Nicholas J. Dyson,Elaine R. Mardis,Armita Bahrami,David H. Ellison,Richard K. Wilson,James R. Downing,Michael A. Dyer,Michael A. Dyer +37 more
TL;DR: It is shown that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated, and that the proto-oncogene SYK is upregulated in retinOBlastoma and is required for tumour cell survival.