Nai Wen Chang

TL;DR: The data suggest that EGFR signaling is important in oral cancer development and that anti-EGFR therapy would benefit patients who carry the 7p11.2 amplicon in their tumors.

TL;DR: Data subsequently attained from this mouse model support a role for alphaB-crystallin and Hsp27 as clinical markers for tumor progression and the study of the promoting effects of arecoline on tongue tumorigenesis.

TL;DR: The results provide the first evidence that the heterozygous A allele of the XRCC4 codon 247 may be associated with the development of oral cancer and may be a novel useful marker for primary prevention and anticancer intervention.

TL;DR: Fenofibrate considerably inhibited metastatic behaviors of CAL 27 cells might be mediated through blocking NF‐κB signaling, resulting in the inhibition of MMPs; these effects were AMPK‐dependent rather than PPARα signaling.

TL;DR: The present study demonstrates that fenofibrate provided novel mechanisms for delaying oral tumor development via the reprogramming of metabolic processes, and provides a molecular rationale whereby fen ofibrate exerts anticancer and additional beneficial effects for the treatment of oral cancer patients.