N
Naoaki Ishii
Researcher at Tokai University
Publications - 129
Citations - 5267
Naoaki Ishii is an academic researcher from Tokai University. The author has contributed to research in topics: Oxidative stress & Caenorhabditis elegans. The author has an hindex of 37, co-authored 127 publications receiving 4927 citations.
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Journal ArticleDOI
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
Naoaki Ishii,Michihiko Fujii,Philip S. Hartman,Michio Tsuda,Kayo Yasuda,Nanami Senoo-Matsuda,Sumino Yanase,Dai Ayusawa,Kenshi Suzuki +8 more
TL;DR: The results indicate that mev-1 governs the rate of ageing by modulating the cellular response to oxidative stress, which may cause an indirect increase in superoxide levels, which in turn leads to oxygen hypersensitivity and premature ageing.
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A Defect in the Cytochrome b Large Subunit in Complex II Causes Both Superoxide Anion Overproduction and Abnormal Energy Metabolism in Caenorhabditis elegans
Nanami Senoo-Matsuda,Kayo Yasuda,Michio Tsuda,Tomoichi Ohkubo,Shinichi Yoshimura,Hiroe Nakazawa,Philip S. Hartman,Naoaki Ishii +7 more
TL;DR: Important biochemical changes in mev-1 animals are reported that serve to explain their abnormalities under normoxic conditions: an overproduction of superoxide anion from mitochondria; and a reciprocal reduction in glutathione content even under atmospheric oxygen.
Journal Article
A Mutation in the SDHC Gene of Complex II Increases Oxidative Stress, Resulting in Apoptosis and Tumorigenesis
TL;DR: The notion that mitochondrially generated oxidative stress can contribute to nuclear DNA damage, mutagenesis, and ultimately, tumorigenesis is underscored.
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A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans
Naoaki Ishii,Kiyoko Takahashi,Satoru Tomita,Tetsuo Keino,Shuji Honda,Kazuhiro Yoshino,Kenshi Suzuki +6 more
TL;DR: It is suggested that oxygen radicals may be involved in the normal aging mechanism in C. elegans and this mutant was also hypersensitive to oxygen.
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Altered Quinone Biosynthesis in the Long-lived clk-1Mutants of Caenorhabditis elegans
Hiroko Miyadera,Hisako Amino,Akira Hiraishi,Hikari Taka,Kimie Murayama,Hideto Miyoshi,Kimitoshi Sakamoto,Naoaki Ishii,Siegfried Hekimi,Kiyoshi Kita +9 more
TL;DR: It is shown that clk-1 mutants mitochondria do not contain detectable levels of UQ9, and the accumulation of DMQ9 and its use in mutant mitochondria indicate a link between the alteration in the quinone species used in respiration and life span.