Sumino Yanase

TL;DR: The results indicate that mev-1 governs the rate of ageing by modulating the cellular response to oxidative stress, which may cause an indirect increase in superoxide levels, which in turn leads to oxygen hypersensitivity and premature ageing.

TL;DR: DAF-16, a forkhead/winged-helix transcription factor, whose expression is suppressed by AGE-1, phosphoinositide 3-kinase (PI3-kinases), regulates anti-oxidant genes as well as energy metabolism under atmospheric conditions, suggests that DAF-16 plays a role in the adaptive response against oxidative stress under hyperoxia.

TL;DR: The fact that DAF-16 translocation by oxidative stress is epistatic to sek-1 suggests that oxidative stress mediates regulation of Daf-16 through activating the p38 signal transduction pathway upstream of daf- 16 so as to mobilize DAF -16 to the nucleus and activate transcription.

TL;DR: The possibility exists that the compensative expression of sod-5 gene in the sod-1 deficit is associated with the insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, which regulates longevity and stress resistance of C. elegans because the sod -5 gene may be a target of the pathway.

TL;DR: It is shown that both mev-1 and gas-1 mutants overproduce superoxide anion in isolated sub-mitochondrial particles, which probably explains their hypersensitivity to oxidative stress.