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Naoko Kikkawa
Researcher at Chiba University
Publications - 48
Citations - 2998
Naoko Kikkawa is an academic researcher from Chiba University. The author has contributed to research in topics: microRNA & Head and neck squamous-cell carcinoma. The author has an hindex of 27, co-authored 44 publications receiving 2691 citations.
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miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma
Masayuki Kano,Naohiko Seki,Naoko Kikkawa,Lisa Fujimura,Isamu Hoshino,Yasunori Akutsu,Takeshi Chiyomaru,Hideki Enokida,Masayuki Nakagawa,Hisahiro Matsubara +9 more
TL;DR: The identification of tumor‐suppressive miRNAs,miR‐145, miR‐133a and miR-133b, directly control oncogenic FSCN1 gene, and could provide new insights into potential mechanisms of ESCC carcinogenesis.
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miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer
Takeshi Chiyomaru,Hideki Enokida,S. Tatarano,Kazuya Kawahara,Yousuke Uchida,Kenryu Nishiyama,Lisa Fujimura,Naoko Kikkawa,Naohiko Seki,Masayuki Nakagawa +9 more
TL;DR: Tumour suppressivemiR-145 and miR-133a directly control oncogenic FSCN1 in BC, and both microRNAs repressed the mRNA and protein expression of F SCN1.
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miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma.
Nijiro Nohata,Yaeko Sone,Toyoyuki Hanazawa,Miki Fuse,Naoko Kikkawa,Hirofumi Yoshino,Takeshi Chiyomaru,Kazumori Kawakami,Hideki Enokida,Masayuki Nakagawa,Makio Shozu,Yoshitaka Okamoto,Naohiko Seki +12 more
TL;DR: The data indicate that TAGLN2 may have an oncogenic function and may be regulated by miR-1, a tumor suppressive miRNA in HNSCC, and the identification of novel mi R-1-regulated cancer pathways could provide new insights into potential molecular mechanisms of H NSCC carcinogenesis.
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miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC).
Naoko Kikkawa,Toyoyuki Hanazawa,Lisa Fujimura,Nijiro Nohata,Hidenori Suzuki,Hideaki Chazono,D. Sakurai,Shigetoshi Horiguchi,Yoshitaka Okamoto,Naohiko Seki +9 more
TL;DR: Identification of the tumour-suppressive miRNA miR-489 and its target, PTPN11, might provide new insights into the underlying molecular mechanisms of HSCC.
Journal ArticleDOI
Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma.
Nijiro Nohata,Toyoyuki Hanazawa,Naoko Kikkawa,Muradil Mutallip,Lisa Fujimura,Hirofumi Yoshino,Kazumori Kawakami,Takeshi Chiyomaru,Hideki Enokida,Masayuki Nakagawa,Yoshitaka Okamoto,Naohiko Seki +11 more
TL;DR: In this paper, a genome-wide gene expression analysis of HNSCC cells that over-express miR-133a showed that CAV1, a multifunctional scaffolding protein, is downregulated, a result that was confirmed by real-time PCR and Western blot analysis.