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Naomi Moris
Researcher at University of Cambridge
Publications - 25
Citations - 1437
Naomi Moris is an academic researcher from University of Cambridge. The author has contributed to research in topics: Embryonic stem cell & Biology. The author has an hindex of 11, co-authored 19 publications receiving 818 citations. Previous affiliations of Naomi Moris include Francis Crick Institute.
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Journal ArticleDOI
Transition states and cell fate decisions in epigenetic landscapes
TL;DR: Here, focusing strictly on the fate decision events, it is suggested that fate transitions occur in a discontinuous, stochastic manner whereby signals modulate the probability of the transition events.
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Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids
Leonardo Beccari,Naomi Moris,Mehmet Girgin,David A. Turner,Peter Baillie-Johnson,Anne-Catherine Cossy,Matthias P. Lutolf,Denis Duboule,Denis Duboule,Alfonso Martinez Arias +9 more
TL;DR: It is shown that small aggregates of mouse embryonic stem cells, when stimulated to undergo gastrulation-like events and elongation in vitro, can organize a post-occipital pattern of neural, mesodermal and endodermal derivatives that mimic embryonic spatial and temporal gene expression.
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An in vitro model of early anteroposterior organization during human development
Naomi Moris,Kerim Anlas,Kerim Anlas,Susanne C. van den Brink,Anna Alemany,Julia Schröder,Julia Schröder,Sabitri Ghimire,Tina Balayo,Tina Balayo,Alexander van Oudenaarden,Alfonso Martinez Arias +11 more
TL;DR: This study shows that human embryonic stem cells can be used to generate gastruloids—three-dimensional multicellular aggregates that differentiate to form derivatives of the three germ layers organized spatiotemporally, without additional extra-embryonic tissues.
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Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids
Susanne C. van den Brink,Anna Alemany,Vincent van Batenburg,Naomi Moris,Marloes Blotenburg,Judith Vivié,Peter Baillie-Johnson,Jennifer Nichols,Katharina F. Sonnen,Alfonso Martinez Arias,Alexander van Oudenaarden +10 more
TL;DR: The power of gastruloids as a model system for exploring development and somitogenesis in vitro in a high-throughput manner is shown, as it can be induced to generate somites with the correct rostral–caudal patterning.
Journal ArticleDOI
Histone Acetyltransferase KAT2A Stabilizes Pluripotency with Control of Transcriptional Heterogeneity
Naomi Moris,Shlomit Edri,Denis Seyres,Rashmi Kulkarni,Ana Filipa Domingues,Tina Balayo,Mattia Frontini,Cristina Pina +7 more
TL;DR: Evidence is shown of a relationship between transcriptional heterogeneity and cell fate transitions through manipulation of the histone acetylation landscape of mouse embryonic stem cells, suggesting a general principle that could be exploited in other normal and malignant stem cell fate transitioned.