M
Mattia Frontini
Researcher at University of Cambridge
Publications - 84
Citations - 7108
Mattia Frontini is an academic researcher from University of Cambridge. The author has contributed to research in topics: Gene & Epigenetics. The author has an hindex of 31, co-authored 74 publications receiving 5390 citations. Previous affiliations of Mattia Frontini include National Institute for Health Research & NHS Blood and Transplant.
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Journal ArticleDOI
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed,Jessica Quintin,Hindrik H. D. Kerstens,Nagesha A.S. Rao,Ali Aghajanirefah,Filomena Matarese,Shih-Chin Cheng,Jacqueline M. Ratter,Kim Berentsen,Martijn van der Ent,Nilofar Sharifi,Eva M. Janssen-Megens,Menno ter Huurne,Amit Mandoli,Tom van Schaik,Aylwin Ng,Aylwin Ng,Frances Burden,Kate Downes,Mattia Frontini,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Willem H. Ouwehand,Jos W. M. van der Meer,Leo A. B. Joosten,Cisca Wijmenga,Joost H.A. Martens,Ramnik J. Xavier,Ramnik J. Xavier,Colin Logie,Mihai G. Netea,Hendrik G. Stunnenberg +31 more
TL;DR: The epigenetic and transcriptional programs of monocyte differentiation to macrophages that distinguish tolerant and trained macrophage phenotypes are uncovered, providing a resource to further understand and manipulate immune-mediated responses.
Journal ArticleDOI
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
William J. Astle,Heather Elding,Heather Elding,Tao Jiang,Dave Allen,Dace Ruklisa,Dace Ruklisa,Alice L. Mann,Daniel Mead,Heleen J. Bouman,Fernando Riveros-Mckay,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,John J. Lambourne,John J. Lambourne,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kate Downes,Kate Downes,Kousik Kundu,Kousik Kundu,Lorenzo Bomba,Kim Berentsen,John Bradley,John Bradley,Louise C. Daugherty,Louise C. Daugherty,Olivier Delaneau,Kathleen Freson,Stephen F. Garner,Stephen F. Garner,Luigi Grassi,Luigi Grassi,Jose A. Guerrero,Jose A. Guerrero,Matthias Haimel,Eva M. Janssen-Megens,Anita Kaan,Mihir A Kamat,Bowon Kim,Amit Mandoli,Jonathan Marchini,Jonathan Marchini,Joost H.A. Martens,Stuart Meacham,Stuart Meacham,Karyn Megy,Karyn Megy,Jared O'Connell,Jared O'Connell,Romina Petersen,Romina Petersen,Nilofar Sharifi,S.M. Sheard,James R Staley,Salih Tuna,Martijn van der Ent,Klaudia Walter,Shuang-Yin Wang,Eleanor Wheeler,Steven P. Wilder,Valentina Iotchkova,Valentina Iotchkova,Carmel Moore,Jennifer G. Sambrook,Jennifer G. Sambrook,Hendrik G. Stunnenberg,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Stephen Kaptoge,Stephen Kaptoge,Taco W. Kuijpers,Enrique Carrillo-de-Santa-Pau,David Juan,Daniel Rico,Alfonso Valencia,Lu Chen,Lu Chen,Bing Ge,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yang,Roderic Guigó,Stephan Beck,Dirk S. Paul,Dirk S. Paul,Tomi Pastinen,David Bujold,Guillaume Bourque,Mattia Frontini,Mattia Frontini,Mattia Frontini,John Danesh,David J. Roberts,David J. Roberts,Willem H. Ouwehand,Adam S. Butterworth,Adam S. Butterworth,Adam S. Butterworth,Nicole Soranzo +103 more
TL;DR: A genome-wide association analysis in the UK Biobank and INTERVAL studies is performed, providing evidence of shared genetic pathways linking blood cell indices with complex pathologies, including autoimmune diseases, schizophrenia, and coronary heart disease and evidence suggesting previously reported population associations betweenBlood cell indices and cardiovascular disease may be non-causal.
Journal ArticleDOI
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
Biola M. Javierre,Oliver S. Burren,Steven P. Wilder,Roman Kreuzhuber,Steven M. Hill,Sven Sewitz,Jonathan Cairns,Steven W. Wingett,Csilla Várnai,Michiel J. Thiecke,Frances Burden,Samantha Farrow,Antony J. Cutler,Karola Rehnström,Kate Downes,Luigi Grassi,Myrto Kostadima,Paula Freire-Pritchett,Fan Wang,Hendrik G. Stunnenberg,John A. Todd,Daniel R. Zerbino,Oliver Stegle,Willem H. Ouwehand,Mattia Frontini,Chris Wallace,Mikhail Spivakov,Peter Fraser +27 more
TL;DR: This work uses promoter capture Hi-C to identify interacting regions of 31,253 promoters in 17 human primary hematopoietic cell types and shows that promoter interactions are highly cell type specific and enriched for links between active promoters and epigenetically marked enhancers.
Journal ArticleDOI
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Lu Chen,Lu Chen,Bing Ge,Francesco Paolo Casale,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yan,Kousik Kundu,Kousik Kundu,Simone Ecker,Avik Datta,David J. Richardson,Frances Burden,Frances Burden,Daniel Mead,Alice L. Mann,José M. Fernández,Sophia Rowlston,Sophia Rowlston,Steven P. Wilder,Samantha Farrow,Samantha Farrow,Xiaojian Shao,John J. Lambourne,Adriana Redensek,Cornelis A. Albers,Vyacheslav Amstislavskiy,Sofie Ashford,Sofie Ashford,Kim Berentsen,Lorenzo Bomba,Guillaume Bourque,David Bujold,Stephan Busche,Maxime Caron,Shu-Huang Chen,Warren A. Cheung,Oliver Delaneau,Emmanouil T. Dermitzakis,Heather Elding,Irina Colgiu,Frederik Otzen Bagger,Frederik Otzen Bagger,Frederik Otzen Bagger,Paul Flicek,Ehsan Habibi,Valentina Iotchkova,Valentina Iotchkova,Eva M. Janssen-Megens,Bowon Kim,Hans Lehrach,Ernesto Lowy,Amit Mandoli,Filomena Matarese,Matthew T. Maurano,John A. Morris,Vera Pancaldi,Farzin Pourfarzad,Karola Rehnström,Karola Rehnström,Augusto Rendon,Thomas Risch,Nilofar Sharifi,Marie-Michelle Simon,Marc Sultan,Alfonso Valencia,Klaudia Walter,Shuang-Yin Wang,Mattia Frontini,Mattia Frontini,Mattia Frontini,Stylianos E. Antonarakis,Laura Clarke,Marie-Laure Yaspo,Stephan Beck,Roderic Guigó,Daniel Rico,Joost H.A. Martens,Willem H. Ouwehand,Taco W. Kuijpers,Taco W. Kuijpers,Dirk S. Paul,Dirk S. Paul,Hendrik G. Stunnenberg,Oliver Stegle,Kate Downes,Kate Downes,Tomi Pastinen,Nicole Soranzo +90 more
TL;DR: High-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types from up to 197 individuals yields insights into cell-type-specific correlation between diverse genomic inputs, more generalizable correlations between these inputs, and defines molecular events that may underpin complex disease risk.
Journal ArticleDOI
Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F]FDG PET Imaging
Jason M. Tarkin,Francis R. Joshi,Nicholas R. Evans,Mohammed M. Chowdhury,Nichola Figg,Aarti V. Shah,Lakshi T Starks,Abel Martin-Garrido,Roido Manavaki,Emma Yu,Rhoda E. Kuc,Luigi Grassi,Roman Kreuzhuber,Myrto Kostadima,Mattia Frontini,Peter J. Kirkpatrick,Patrick A. Coughlin,Deepa Gopalan,Tim D. Fryer,John R. Buscombe,Ashley M. Groves,Willem H. Ouwehand,Martin R. Bennett,Elizabeth A. Warburton,Anthony P. Davenport,James H.F. Rudd +25 more
TL;DR: It is confirmed that 68Ga-DOTATATE offers superior coronary imaging, excellent macrophage specificity, and better power to discriminate high-risk versus low-risk coronary lesions than [18F]FDG.