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Naruhiko Adachi
Researcher at KEK
Publications - 42
Citations - 648
Naruhiko Adachi is an academic researcher from KEK. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 10, co-authored 31 publications receiving 390 citations. Previous affiliations of Naruhiko Adachi include University of Tokyo.
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Journal ArticleDOI
Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.
Saku Miyamoto,Toru Suzuki,Shinsuke Muto,Kenichi Aizawa,Akatsuki Kimura,Yoshiko Mizuno,Tomoko Nagino,Yasushi Imai,Naruhiko Adachi,Masami Horikoshi,Ryozo Nagai +10 more
TL;DR: A new pathway for regulation of a DNA-binding transcription factor on the DBD is suggested through interaction and coupled acetylation by two opposing regulatory factors of a coactivator/acetylase and a negative cofactor harboring activity to inhibit acetylations.
Journal ArticleDOI
Crystal Structure of the Human BRD2 Bromodomain INSIGHTS INTO DIMERIZATION AND RECOGNITION OF ACETYLATED HISTONE H4
Yoshihiro Nakamura,Takashi Umehara,Kazumi Nakano,Moon Kyoo Jang,Mikako Shirouzu,Satoshi Morita,Hiroko Uda-Tochio,Hiroaki Hamana,Takaho Terada,Naruhiko Adachi,Takehisa Matsumoto,Akiko Tanaka,Masami Horikoshi,Keiko Ozato,Balasundaram Padmanabhan,Shigeyuki Yokoyama +15 more
TL;DR: The crystal structure of the N-terminal bromodomain (BD1, residues 74-194) of human BRD2 is reported, which is the first observation of a homodimer among the known bromidomain structures, through the buried hydrophobic core region at the interface.
Journal ArticleDOI
Discovery of non-squalene triterpenes
Hui Tao,Lukas Lauterbach,Guangkai Bian,Rong Chen,An-Ting Hou,Takahiro Ohta-ku Mori,Shuhan Cheng,Ben Hu,Li Lu,Xin Mu,Min Li,Naruhiko Adachi,Masato Kawasaki,Toshio Moriya,Toshiya Senda,Xing-Zheng Wang,Zixin Deng,Ikuro Abe,Jeroen S. Dickschat,Tianhui Liu +19 more
TL;DR: In this article , two fungal chimeric class I triterpene synthases, Talaromyces verruculosus talaropentaene synthase (TvTS) and Macrophomina phaseolina macrophomene synthesis (MpMS), were characterized.
Journal ArticleDOI
Discovery of non-squalene triterpenes
Hui Tao,Lukas Lauterbach,Guangkai Bian,Rong Chen,An-Ting Hou,Takahiro Ohta-ku Mori,Shuhan Cheng,Ben Hu,Li Lu,Xin Mu,Min Li,Naruhiko Adachi,Masato Kawasaki,Toshio Moriya,Toshiya Senda,Xing-Zheng Wang,Zi-Wei Deng,Ikuro Abe,Jeroen S. Dickschat,Tianhui Liu +19 more
TL;DR: In this article , two fungal chimeric class I triterpene synthases, Talaromyces verruculosus talaropentaene synthase (TvTS) and Macrophomina phaseolina macrophomene synthesis (MpMS), were characterized.
Journal ArticleDOI
Structural analysis reveals TLR7 dynamics underlying antagonism
Shingo Tojo,Z. Zhang,Hiroyuki Matsui,Masahiro Tahara,Mitsunori Ikeguchi,Mami Kochi,Mami Kamada,Hideki Shigematsu,Akihisa Tsutsumi,Naruhiko Adachi,Takuma Shibata,Masaki Yamamoto,Masahide Kikkawa,Toshiya Senda,Yoshiaki Isobe,Umeharu Ohto,Toshiyuki Shimizu +16 more
TL;DR: This work identifies the open conformation of the receptor and reveals the structural equilibrium between open and closed conformations that underlies TLR7 antagonism, as well as the detailed mechanism by which TLR 7-specific antagonists bind to their binding pocket inTLR7.