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Nastya Kharlamova
Researcher at Karolinska Institutet
Publications - 23
Citations - 572
Nastya Kharlamova is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Porphyromonas gingivalis & Antibody. The author has an hindex of 7, co-authored 19 publications receiving 449 citations. Previous affiliations of Nastya Kharlamova include Karolinska University Hospital.
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Journal ArticleDOI
Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile
Karin Lundberg,Camilla Bengtsson,Nastya Kharlamova,Evan Reed,Xia Jiang,Henrik Källberg,Iskra Pollak-Dorocic,Lena Israelsson,Christoph Kessel,Leonid Padyukov,Rikard Holmdahl,Lars Alfredsson,Lars Klareskog +12 more
TL;DR: This study provides the most comprehensive picture to date of how HLA-DRB1 SE, PTPN22 and smoking are associated with the presence of specific ACPA reactivities rather than anti-CCP levels.
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Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology
Nastya Kharlamova,Xia Jiang,Natalia Sherina,Barbara Potempa,Lena Israelsson,Anne-Marie Quirke,Kaja Eriksson,Tülay Yucel-Lindberg,Patrick J Venables,Jan Potempa,Lars Alfredsson,Karin Lundberg +11 more
TL;DR: The antibody response to the P gingivalis virulence factor arginine gingipain type B (RgpB) in relation to anti–citrullinated protein antibodies (ACPAs), smoking, and HLA–DRB1 shared epitope (SE) alleles in patients with periodontitis, patients with RA, and controls is analyzed.
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Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis.
Linda Johansson,Natalia Sherina,Nastya Kharlamova,Barbara Potempa,Barbro Larsson,Lena Israelsson,Jan Potempa,Jan Potempa,Solbritt Rantapää-Dahlqvist,Karin Lundberg +9 more
TL;DR: Investigation of whether anti-P.
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Antibodies to carbamylated α-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies
Evan Reed,Xia Jiang,Nastya Kharlamova,A. Jimmy Ytterberg,Anca I. Catrina,Lena Israelsson,Linda Mathsson-Alm,Linda Mathsson-Alm,Monika Hansson,Lars Alfredsson,Lars Alfredsson,Johan Rönnelid,Karin Lundberg +12 more
TL;DR: Affinity-purified ACPA was found to bind carbamylated proteins and homocitrulline-containing peptides, demonstrating definitive cross-reactivity between ACPA and anti-CarP antibodies.
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Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint
Elena Ossipova,C. Cerqueira,Evan Reed,Nastya Kharlamova,Lena Israelsson,Rikard Holmdahl,Kutty Selva Nandakumar,Marianne Engström,Ulrike Harre,Georg Schett,Anca I. Catrina,Vivianne Malmström,Yngve Sommarin,Lars Klareskog,Per-Johan Jakobsson,Karin Lundberg +15 more
TL;DR: It is demonstrated that the surrogate marker CCP2 can capture ACPAs that bind to autoantigens expressed in vivo in the major inflammatory lesions of RA (that is, in the rheumatoid joint) and that the purified ACPA bound not only in vitro citrullinated proteins but, more importantly, in vivo-generated epitopes on synovial fluid cells andsynovial tissues from patients with RA.