N
Natalie Roy
Researcher at University of Ottawa
Publications - 10
Citations - 2249
Natalie Roy is an academic researcher from University of Ottawa. The author has contributed to research in topics: SMA* & NAIP. The author has an hindex of 7, co-authored 10 publications receiving 2224 citations. Previous affiliations of Natalie Roy include Children's Hospital of Eastern Ontario & Mackenzie Investments.
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Journal ArticleDOI
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
Peter Liston,Natalie Roy,Katsuyuki Tamai,Charles Lefebvre,Charles Lefebvre,Stephen Baird,Cherton-Horvat G,Cherton-Horvat G,Ramin Mostofi Zadeh Farahani,Ramin Mostofi Zadeh Farahani,M. McLean,Joh-E Ikeda,Alex MacKenzie,Alex MacKenzie,Robert G. Korneluk,Robert G. Korneluk +15 more
TL;DR: A NAIP-mediated inhibition of apoptosis induced by a variety of signals is demonstrated, and three additional human complementary DNAs and a Drosophila melanogaster sequence that are also homologous to the baculovirus lAPs are identified.
Journal ArticleDOI
The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
Natalie Roy,Natalie Roy,Mani S. Mahadevan,Michael Mclean,Michael Mclean,Gary Shutter,Zahra Yaraghi,Zahra Yaraghi,Reza Farahani,Reza Farahani,Stephen Baird,Anne Besner-Johnston,Charles Lefebvre,Charles Lefebvre,Xiaolin Kang,Xiaolin Kang,Maysoon Salih,Huguette L. Aubry,Katsuyuki Tamai,Xiaoping Guan,Panayiotis A. Ioannou,Thomas O. Crawford,Pieter J. de Jong,Linda C. Surh,Joh-E Ikeda,Joh-E Ikeda,Robert G. Korneluk,Robert G. Korneluk,Alex MacKenzie,Alex MacKenzie +29 more
TL;DR: It is suggested that mutations in the NAIP locus may lead to a failure of a normally occurring inhibition of motor neuron apoptosis resulting in or contributing to the SMA phenotype.
Journal ArticleDOI
Refined physical map of the spinal muscular atrophy gene (SMA) region at 5q13 based on YAC and cosmid contiguous arrays
Natalie Roy,Michael Mclean,Anne Besner-Johnston,Charles Lefebvre,Maysoon Salih,John D. Carpten,Arthur H.M. Burghes,Arthur H.M. Burghes,Zahra Yaraghi,Joh-E Ikeda,Joh-E Ikeda,Robert G. Korneluk,Robert G. Korneluk,Alex MacKenzie,Alex MacKenzie +14 more
TL;DR: The gene for the autosomal recessive neurodegenerative disorder spinal muscular atrophy has been mapped to a region of 5q13 flanked proximally by CMS-1 and distally by D5S557, indicating that the gene is located in close proximity to or within the cosmid clone array.
Journal ArticleDOI
Two 5q13 simple tandem repeat loci are in linkage disequilibrium with Type 1 spinal muscular atrophy
Michael Mclean,Natalie Roy,Alexander E.MacKenzle,Maysoon Salih,Arthur H.M. Burghes,Louise R. Simard,Robert G.Kornelukw,Robert G.Kornelukw,Joh-E. lkeda,Linda Surh +9 more
TL;DR: The genotyping of 149 SMA Type 1 chromosomes and 142 normal chromosomes from Canadian and American kindreds reveals the presence of significant linkage disequilibrium between the null allele of the sublocus referred to as CATT-40G1 and mutation(s) causing S MA Type 1 (Werdnig-Hoffmann disease).
Patent
Neuronal apoptosis inhibitor protein, gene sequence and mutations causative of spinal muscular atrophy
TL;DR: The gene for the autosomal recessive neurodegenerative disorder Spinal Muscular Atrophy (SMA) has been mapped to a region of chromosome 5 as mentioned in this paper.