Nathalie Charland

TL;DR: Isogenic mutants defective in capsule production demonstrate the importance of capsular polysaccharides as a virulence factor for S. suis type 2.

TL;DR: Invasion assays performed with BMEC and human umbilical vein endothelial cells demonstrated that unlike GBS, S. suisserotype 2 could not invade either type of cell, and it is possible that hemolysin-positive S.suis strains use adherence and suilysin-induced BMEC injury, as opposed to direct cellular invasion, to proceed from the circulation to the central nervous system.

TL;DR: It is demonstrated that immunization of mice with BVH-3 elicits protective immunity against experimental sepsis and pneumonia, and BVh-3 and the chimeric protein hold strong promise as vaccine components to control pneumococcal disease.

TL;DR: It is suggested that the Pht proteins are zinc and manganese scavengers, and are able to store these metals and to release them when the bacterium faces an ion-restricted environment.

TL;DR: The CoVLP+AS03 vaccine was effective in preventing Covid-19 caused by a spectrum of variants, with efficacy ranging from 69.5% against symptomatic infection to 78.8% against moderate-to-severe disease.