Nathalie Faisant

TL;DR: Based on experimental findings, the most important underlying drug release rate controlling mechanisms were identified and a new mathematical model was developed that allows the quantitative description of the resulting release patterns.

TL;DR: Investigation of the effect of the size of biodegradable microparticles (monolithic dispersions) on the release rate of an incorporated drug in a quantitative way revealed that the degradation behavior of the matrix forming polymer was not significantly affected by the sizes of the devices and that autocatalytic effects do not seem to play a major role.

TL;DR: A new, mechanistic mathematical model was developed that allows further insight into the release mechanisms in bioerodible microparticles that is able to describe the observed drug release kinetics accurately over the entire period of time.

TL;DR: The compatibility of poly(lactide-co-glycolide) microspheres with brain tissues is established, which means that these microparticles can be easily implanted by stereotaxy in discreet, precise and functional areas of the brain without damaging the surrounding tissue.

TL;DR: Based on the obtained knowledge the selection of an appropriate release medium for in vitro tests simulating in vivo conditions can be facilitated, and "stress tests" can be developed allowing to get rapid feedback on the release characteristics of a specific batch.